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靛玉红对肿瘤血管内皮细胞增殖、迁移、血管形成的影响
Authors Li Z, Zhu C, An B, Chen Y, He X, Qian L, Lan L, Li S
Received 23 November 2017
Accepted for publication 11 March 2018
Published 18 May 2018 Volume 2018:11 Pages 2937—2944
DOI https://doi.org/10.2147/OTT.S157949
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Geoffrey Pietersz
目的：探讨靛玉红（Indirubin）对肿瘤血管内皮细胞增殖、迁移、血管形成影响。
方法：采用肝癌 HepG2 细胞上清诱导人脐静脉内皮细胞（human umbilical vein
endothelial cells, HUVEC）成为肿瘤血管内皮细胞（tumor-derived endothelial cells,
Td-EC），通过 MTT 法、细胞迁徙试验、血管形成实验检测靛玉红对 HUVEC 与 Td-EC 增殖、迁移、血管形成的影响。
结果：靛玉红在体外对 Td-EC 有显著的生长抑制作用，并具有时间和浓度依赖性；一定浓度的靛玉红能显著降低 Td-EC 细胞迁徙活性和抑制血管的形成，而同样条件下，靛玉红对 HUVEC 的抑制作用弱于 Td-EC。
结论：靛玉红在体外可特异地抑制 Td-EC 增殖、迁移、血管形成。
Keywords: indirubin,
Td-EC, proliferation, migration, invasion, angiogenesis
