Objective: This study was to investigate the expression and clinical significance of RRBP1 in esophageal carcinoma. 
Materials and methods: RRBP1 expression was detected in 120 esophageal carcinoma and matched adjacent normal tissues, and the relationship of RRBP1 with clinicopathological characteristics and prognosis was analyzed. 
Results: RRBP1 was highly expressed in esophageal carcinoma tissues compared with matched adjacent normal tissues (P <0.05). Moreover, RRBP1 expression was associated with T stage, lymph node metastasis, and TNM stage in esophageal carcinoma (P <0.05). Survival analysis revealed that RRBP1, T stage, lymph node metastasis, and TNM stage were significantly associated with patients’ prognosis. 
Conclusion: RRBP1 is highly expressed in esophageal carcinoma and can serve as a potential biomarker to predict patients’ prognosis.
Keywords: RRBP1, prognosis, esophageal carcinoma, survival analysis