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Authors Chen Q, Yuan H, Shi GD, Wu Y, Liu D, Lin YT, Chen L, Ge W, Jiang K, Miao Y
Received 22 November 2017
Accepted for publication 10 March 2018
Published 9 May 2018 Volume 2018:11 Pages 2709—2723
DOI https://doi.org/10.2147/OTT.S157759
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 3
Editor who approved publication: Dr XuYu Yang
Background: Previous studies have reported that nuclear receptor subfamily 5,
group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C,
rs12029406 C>T) are associated with the risk of pancreatic cancer. However,
the results of epidemiological investigations are still controversial. In order
to explore its potential attributing factors, we pooled the updated literatures
to evaluate the association between NR5A2 polymorphism and the risk of
pancreatic cancer in this meta-analysis.
Materials and
methods: Databases such as PubMed,
Google Scholar and China National Knowledge Infrastructure were searched for
eligible articles following strict inclusion and exclusion criteria (updated to
November 18, 2017). Odds ratios (ORs) and 95% CIs were computed to assess the
intensity of association. In addition, heterogeneity, sensitivity analysis and
publication bias were explored. All statistical analyses were conducted by
STATA 14.0.
Results: Our results showed that the rs3790843 (GA vs GG: OR=0.86,
CI=0.76–0.98, P =0.992; GA+AA vs
GG: OR=0.83, CI=0.73–0.94, P =0.950; A vs G:
OR=0.85, CI=0.78–0.93, P =0.802), rs3790844
(CC vs TT: OR=0.65, CI=0.54–0.78, P =0.617; CC vs
TT+CT: OR=0.73, CI=0.62–0.85, P =0.742; C vs T:
OR=0.78, CI=0.73–0.84, P =0.555) and
rs12029406 (TT vs CC: OR=0.73, CI=0.61–0.89, P =0.483;
TT vs CC+CT: OR=0.78, CI=0.66–0.92, P =0.648; T vs C:
OR=0.87, CI=0.79–0.95, P =0.837)
polymorphisms were associated statistically with the risk of pancreatic cancer.
Furthermore, the results of subgroup analysis showed that rs3790843 and
rs3790844 polymorphisms were especially related to the risk of pancreatic
cancer in Caucasian population.
Conclusion: Our results revealed that NR5A2 may have a protective effect on
pancreatic cancer. However, more well-designed researches are needed to verify
the relationship between NR5A2 polymorphisms and the risk of pancreatic cancer.
Keywords: NR5A2, polymorphism, rs3790844, pancreatic cancer, meta-analysis