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Authors Tang L, Li HJ, Huang X, Bao J, Sethi Z, Ye L, Yuan Q, Zhu PW, Jiang N, Gao GP, Shao Y
Received 9 November 2017
Accepted for publication 30 January 2018
Published 20 April 2018 Volume 2018:11 Pages 843—850
DOI https://doi.org/10.2147/JPR.S156634
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Minal Joshi
Peer reviewer comments 2
Editor who approved publication: Dr Katherine Hanlon
Objective: Previous neuroimaging studies have demonstrated that pain-related
diseases are associated with brain function and anatomical abnormalities,
whereas altered synchronous neural activity in acute eye pain (EP) patients has
not been investigated. The purpose of this study was to explore whether or not
synchronous neural activity changes were measured with the regional homogeneity
(ReHo) method in acute EP patients.
Methods: A total of 20 patients (15 males and 5 females) with EP and 20 healthy
controls (HCs) consisting of 15 and 5 age-, sex-, and education-matched males
and females, respectively, underwent resting-state functional magnetic
resonance imaging. The ReHo method was applied to assess synchronous neural
activity changes.
Results: Compared with HCs, acute EP patients had significantly lower ReHo values
in the left precentral/postcentral gyrus (Brodmann area [BA]3/4), right
precentral/postcentral gyrus (BA3/4), and left middle frontal gyrus (BA6). In
contrast, higher ReHo values in acute EP patients were observed in the left
superior frontal gyrus (BA11), right inferior parietal lobule (BA39/40), and
left precuneus (BA7). However, no relationship was found between the mean ReHo
signal values of the different areas and clinical manifestations, which
included both the duration and degree of pain in EP patients.
Conclusion: Our study highlighted that acute EP patients showed altered
synchronous neural activities in many brain regions, including somatosensory
regions. These findings might provide useful information for exploration of the
neural mechanisms underlying acute EP.
Keywords: acute eye pain, corneal pain, regional homogeneity, resting state,
functional magnetic resonance imaging