论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Xia Q, Wang W, Xu J, Chen X, Zhong Z, Sun C
Received 11 October 2017
Accepted for publication 10 February 2018
Published 19 April 2018 Volume 2018:11 Pages 2251—2257
DOI https://doi.org/10.2147/OTT.S153759
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Geoffrey Pietersz
Background: Radiotherapy and chemotherapy are the two important postoperative
management approaches for anaplastic thyroid carcinoma (ATC), and several
studies have suggested that postoperative radiotherapy and chemotherapy can
prolong the survival of patients with ATC. However, the results remain
inconsistent.
Objective: A meta-analysis was performed to address whether
postoperative radiotherapy and chemotherapy could prolong the survival of
patients with ATC.
Methods: Relevant studies were included, and pooled
hazard ratios (HRs) together with 95% confidence intervals (CIs) were
calculated.
Results: Ten relevant studies on factors that affect the
prognosis for ATC were included in this meta-analysis, evaluating a total of
1,163 patients. The pooled HR for overall survival (OS) was calculated using a
random-effects model. The pooled results demonstrated that for all patients
with resectable ATC, the combination of surgery and radiotherapy significantly
reduced the risk of death compared with surgery alone (HR =0.51, 95% CI:
0.36–0.73, Z =3.66, P =0.0002). To investigate the
prognostic impacts of chemotherapy in patients with ATC, we also calculated the
pooled HR of chemotherapy for OS using a random-effects model; however, the
pooled results suggested that chemotherapy did not prolong the survival of ATC
patients compared with controls (HR =0.63, 95% CI: 0.33–1.21, Z =1.39, P =0.17).
Conclusion: This study provided evidence that currently, for
patients with ATC, postoperative radiotherapy may prolong survival; in
contrast, chemotherapy did not improve long-term survival.
Keywords: anaplastic
thyroid carcinoma, postoperative radiotherapy, chemotherapy, prognosis,
meta-analysis