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Authors Bakshi N, Lukombo I, Belfer I, Krishnamurti L
Received 8 September 2017
Accepted for publication 15 January 2018
Published 8 May 2018 Volume 2018:11 Pages 947—953
DOI https://doi.org/10.2147/JPR.S151198
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Minal Joshi
Peer reviewer comments 2
Editor who approved publication: Dr Michael Schatman
Background: Sickle cell disease (SCD) is an inherited disorder of the red
blood cells and is associated with chronic multisystem involvement. While SCD
has been associated with poorer health-related quality of life (HRQoL), there
is a paucity of data on the relationship of psychological covariates other than
anxiety and depression and quality of life (QoL) in children with SCD.
Materials and
methods: We performed a cross-sectional study
of psychological factors, HRQoL, and pain-related outcomes in participants with
SCD and race-matched controls as part of a larger study of experimental pain
phenotyping.
Results: Pain catastrophizing was inversely correlated with HRQoL measured
by the PedsQL™ Generic Core Scale in children with SCD, while this was not
noted in control participants. Psychological factors, such as anxiety and
depressive symptoms, were also associated with poorer HRQoL in both children
with SCD and controls. We did not find an association of psychological factors
with prior health care utilization. Psychological factors such as anxiety and
depressive symptoms were inversely correlated with pain interference, but not
pain intensity in SCD.
Conclusion: Catastrophizing is associated with poorer HRQoL in SCD, but in
this study, it was not associated with pain intensity or interference and
health care utilization in children with SCD. Further studies are needed to
fully define the association of psychological factors including catastrophizing
with QoL, pain burden, and SCD outcomes.
Keywords: pain, depressive symptoms, catastrophizing, sickle cell disease,
PROMIS, quality of life