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Authors Huang Y, Song G, Chang X, Wang Z, Zhang X, Han S, Su Z, Yang H, Yang D, Zhang X
Received 15 January 2018
Accepted for publication 13 March 2018
Published 3 May 2018 Volume 2018:13 Pages 2665—2684
DOI https://doi.org/10.2147/IJN.S162558
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Background: Poor mechanical properties, undesirable fast dissolution rate, and
lack of antibacterial activity limit the application of hydroxyapatite (HA) as
an implant coating material. To overcome these limitations, a hybrid coating of
Ag+-substituted
fluorhydroxyapatite and titania nanotube (TNT) was prepared.
Methods: The incorporation of silver into the HA-TiO2 hybrid coating improves its antimicrobial properties. The addition
of F as a second binary element increases the structural stability of the
coating. The TNT/F-and-Ag-substituted HA (FAgHA) bilayer coating on the Ti
substrate was confirmed by X-ray diffraction, scanning electron microscope,
energy-dispersive X-ray spectroscopy (EDS), and X-ray photoelectron
spectroscopy (XPS).
Results: The results indicate that the FAgHA/TNT nanocomposite coating has a
dense and uniform morphology with a nano-rod-like structure. The solubility
measurement result shows that the substitution of F- ions into the AgHA structure has a positive effect on the
dissolution resistance of HA. The adhesion strength of FAgHA/TNT has
significantly increased because of the interlocking of the roughened surface
with nano-rod-like particles that entered into the voids of the TiO2 nanotubes. Compared with that of the bare Ti, the corrosion
current density of FAgHA/TNT-coated Ti substrate decreased from 3.71 to 0.18
µA, and its corrosion resistance increased by almost two orders of magnitude.
Moreover, despite pure HA, the FAgHA killed all viable Staphylococcus aureus after
24 hours of incubation. Although the fabricated FAgHA/TNT coating is
hydrophobic, it induced deposition of the typical spherical apatite when
immersed in a simulated body fluid (SBF); the osteoblasts spread very well on
the surface of the coating. In addition, in vitro cell culture tests
demonstrated cell viability and alkaline phosphatase (ALP) similar to pure HA,
which indicated good cytocompatibility. Interestingly, compared with bare Ti,
FAgHA/TNT-coated Ti surface was innocent for cell vitality and even more
beneficial for cell osteogenesis in vitro.
Conclusion: Enhancing the osseointegration and preventing infection in
implants, the FAgHA/TNT-coated Ti makes implants more successful.
Keywords: titania nanotube, silver, fluorhydroxyapatite, bactericidal
effects, osteoinductivity