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已发表论文
Hippo 信号通路在乳腺癌转移中的作用
Authors Wei C, Wang Y, Li X
Received 14 November 2017
Accepted for publication 7 March 2018
Published 17 April 2018 Volume 2018:11 Pages 2185—2193
DOI https://doi.org/10.2147/OTT.S157058
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr XuYu Yang
Abstract: The Hippo
pathway is a novel and highly conserved mammalian signaling pathway. Mutations
and altered expression of core Hippo pathway components promote the migration,
invasion, malignancy, and chemotherapy resistance of breast cancer cells. In
cancer metastasis, tumor cells must detach from the primary tumor, invade
surrounding tissue, and enter and survive in a foreign microenvironment. The
metastatic potential of breast cancer is closely related to individual patient
genetic profile. Nevertheless, the exact molecular mechanism that regulates the
Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This
article discusses the function and regulation of the Hippo pathway, with focus
given to its role in the context of breast cancer metastasis.
Keywords: breast cancer, Hippo signal pathway, metastasis
Keywords: breast cancer, Hippo signal pathway, metastasis
