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关于肝癌自发消退的可能的病因学线索：从病理学的角度

 

Authors Wang Z, Ke ZF, Lu XF, Luo CJ, Liu YD, Lin ZW, Wang LT

Published Date February 2015 Volume 2015:8 Pages 395—400

DOI http://dx.doi.org/10.2147/OTT.S79102

Received 11 December 2014, Accepted 12 January 2015, Published 5 February 2015

Abstract: Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event. However, only a few of the causes of cases of HCC spontaneous regression are clear. More cases are ambiguous. We report on a patient who had a spontaneous regression of HCC as detected by histological and immunohistochemical exam, and compared this case to 20 cases of non-specific HCC. In our case, we found that the odd phenomenon is that CD163+ macrophages are overactivated in surviving HCC, which is spontaneously regressing. Concomitantly, we cannot find a similar phenomenon in peritumoral liver tissue or non-specific HCC. According to our microscopical morphology and immunohistochemical study, we considered that a clue of a possible etiology about HCC spontaneous regression is that CD163+ macrophages are overactivated.
Keywords: hepatocellular carcinoma, spontaneous regression, macrophages, CD163, CD68






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