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Authors Huang H, Li T, Liao D, Zhu Z, Dong Y
Received 30 July 2017
Accepted for publication 22 January 2018
Published 12 April 2018 Volume 2018:10 Pages 755—763
DOI https://doi.org/10.2147/CMAR.S147751
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 3
Editor who approved publication: Professor Kenan Onel
Background: Accumulating evidence has suggested a relationship between
calcium-sensing receptor (CASR ) polymorphisms
and cancer risk in different types of cancer; however, the findings from
epidemiologic studies have been conflicting. The purpose of this meta-analysis
was to assess the clinical susceptibility of CASR polymorphisms
in cancer patients.
Materials and
methods: This study systematically searched
MEDLINE and EMBASE databases for eligible articles through March 2017. The
strength of association was expressed as odds ratio and 95% CI. Publication
bias, heterogeneity, sensitivity analysis, and subgroup analyses were also
examined.
Results: Fourteen related case–control studies were finally identified to
be included in the present analysis. The pooled result showed that no
significant associations were found among CASR rs1801725,
rs1042636, rs12485716, rs4678174, rs1801726, rs17251221, rs10934578, and
rs2270916 polymorphisms and cancer risk under all genetic models (P >0.05). The relationship between CASR rs1801725 polymorphism
and risk of cancer was consistent in the subgroup analyses, and robust in
sensitivity analysis. No publication bias was presented in our
pooled-analysis.
Conclusion: The current evidence for our pooled analysis suggests that
the CASR polymorphisms are not
associated with an increased risk of cancer. Further larger studies are still
necessary to warrant and validate the findings in the current meta-analysis.
Keywords: calcium-sensing receptor, polymorphism, cancer, susceptibility,
meta-analysis