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Authors Liu Q, Kong F, Zhou J, Dong M, Dong Q
Received 13 December 2017
Accepted for publication 31 January 2018
Published 12 April 2018 Volume 2018:10 Pages 735—743
DOI https://doi.org/10.2147/CMAR.S159689
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Leylah Drusbosky
Abstract: Gastrointestinal stromal tumors (GISTs) are relatively common
mesenchymal tumors. They originate from the wall of hollow viscera and may be
found in any part of the digestive tract. The prognosis of patients with
stromal tumors depends on various risk factors, including size, location,
presence of mitotic figures, and tumor rupture. Emergency surgery is often required
for stromal tumors with hemorrhage. The current literature suggests that
stromal tumor hemorrhage indicates poor prognosis. Although the optimal
treatment options for hemorrhagic GISTs are based on surgical experience, there
remains controversy with regard to optimum postoperative management as well as
the classification of malignant potential. This article reviews the biological
characteristics, diagnostic features, prognostic factors, treatment, and
postoperative management of GISTs with hemorrhage.
Keywords: GIST,
hemorrhage of digestive tract, prognosis, targeted therapy