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Authors Yang KR, Han Q, Chen B, Zheng Y, Zhang K, Li Q, Wang JC
Received 21 October 2017
Accepted for publication 24 January 2018
Published 12 April 2018 Volume 2018:13 Pages 2217—2263
DOI https://doi.org/10.2147/IJN.S154748
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Govarthanan Muthusamy
Peer reviewer comments 3
Editor who approved publication: Dr Linlin Sun
Abstract: The rapid emergence of
antibiotic resistance in pathogenic microbes is becoming an imminent global
public health problem. Local application of antibiotics might be a solution. In
local application, materials need to act as the drug delivery system. The drug
delivery system should be biodegradable and prolonged antibacterial effect
should be provided to satisfy clinical demand. Hydrogel is a promising material
for local antibacterial application. Hydrogel refers to a kind of biomaterial
synthesized by a water-soluble natural polymer or a synthesized polymer, which
turns into gel according to the change in different signals such as
temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high
hydrophilicity, unique three-dimensional network, fine biocompatibility and
cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery
in antimicrobial areas. In this review, studies from the past 5 years were
reviewed, and several types of antimicrobial hydrogels according to different
ingredients, different preparations, different antimicrobial mechanisms,
different antimicrobial agents they contained and different applications, were
summarized. The hydrogels loaded with metal nanoparticles as a potential method
to solve antibiotic resistance were highlighted. Finally, future prospects of
development and application of antimicrobial hydrogels are suggested.
Keywords: nanomaterials,
hydrogels, nanoparticles, antibiotics, drug delivery, infection