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Authors Cheng Y, Zhang J, Geng HY, Qin SK, Hua HQ
Received 26 November 2017
Accepted for publication 22 February 2018
Published 6 April 2018 Volume 2018:11 Pages 1989—1995
DOI https://doi.org/10.2147/OTT.S158141
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr XuYu Yang
Abstract: The aim of this study was to
observe the efficacy and safety of apatinib combined with toptecan therapy in
the multiline treatment of platinum-resistant recurrent ovarian cancer
patients. The clinical records of three patients with platinum-resistant
recurrent ovarian cancer treated with apatinib combined with toptecan therapy
were analyzed and followed up for 3 months, and the related literatures were
reviewed. The three patients achieved partial response and the tumor marker
CA125 levels decreased significantly as an outcome of the treatment. Major
adverse reactions were hypertension, hand–foot skin reaction, and anemia, which
were manageable with medication. Apatinib combined with toptecan multiline
therapy in the treatment of platinum-resistant recurrent ovarian cancer
patients is effective, and the adverse effects are tolerated. Large-scale studies
should be conducted to further determine the efficacy and safety of this
treatment protocol.
Keywords: ovarian cancer,
apatinib, topotecan, gynecological oncology