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Authors Lai JB, Zhou WH, Lu QQ, Huang TT, Xu Y, Hu SH
Received 11 September 2017
Accepted for publication 19 January 2018
Published 5 April 2018 Volume 2018:14 Pages 933—936
DOI https://doi.org/10.2147/NDT.S151396
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 3
Editor who approved publication: Professor Wai Kwong Tang
Background: Constipation is a common
clinical problem with insufficient attention. Medication-emergent constipation
is a rarely studied adverse reaction in patients with obsessive-compulsive
disorder (OCD).
Methods: In this descriptive study, we retrospectively
investigated the prevalence of laxative use and its relationship with clinical
characteristics in hospitalized OCD patients. A total of 51 OCD patients were
included in the final analysis.
Results: The proportion of patients using laxatives was 31.4%,
and the commonly used laxatives were phenolphthalein tablet, lactulose and
congrongtongbian oral liquid (a patent herbal medicine). In the laxative group,
hospital stays were longer when compared to the nonlaxative group. Moreover,
the dose of paroxetine was higher in patients treated with laxatives than in
those without laxative use. Correlation analysis indicated that laxative use
was positively associated with hospital stays, as well as the dose of
paroxetine.
Conclusion: The current study provided a preliminary picture
of constipation and laxative use in hospitalized OCD patients. Close monitoring
and treatment of constipation are recommended in OCD patients with
pharmacotherapy.
Keywords: obsessive-compulsive
disorder, constipation, laxative, hospital stay, paroxetine