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Authors Li Y, Lin Z, Guo M, Zhao M, Xia Y, Wang C, Xu T, Zhu B
Received 3 November 2017
Accepted for publication 26 January 2018
Published 3 April 2018 Volume 2018:13 Pages 2005—2016
DOI https://doi.org/10.2147/IJN.S155994
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Govarthanan Muthusamy
Peer reviewer comments 3
Editor who approved publication: Dr Lei Yang
Introduction: As
a therapeutic antiviral agent, the clinical application of amantadine (AM) is
limited by the emergence of drug-resistant viruses. To overcome the
drug-resistant viruses and meet the growing demand of clinical diagnosis, the
use of biological nanoparticles (NPs) has increased in order to develop novel
anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity
and excellent activities has attracted increasing attention for biomedical
intervention in recent years.
Methods and
results: In the present study, surface
decoration of selenium NPs by AM (Se@AM) was designed to reverse drug
resistance caused by influenza virus infection. Se@AM with less toxicity
remarkably inhibited the ability of H1N1 influenza to infect host cells through
suppression of the neuraminidase activity. Moreover, Se@AM could prevent H1N1
from infecting Madin Darby Canine Kidney cell line and causing cell apoptosis
supported by DNA fragmentation and chromatin condensation. Furthermore, Se@AM
obviously inhibited the generation of reactive oxygen species and activation of
phosphorylation of AKT.
Conclusion: These results demonstrate that Se@AM is a potentially efficient
antiviral pharmaceutical agent for H1N1 influenza virus.
Keywords: selenium nanoparticles, amantadine, influenza virus, apoptosis, nanodrug