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Authors Li Y, Zhang W, Liu P, Xu Y, Tang L, Chen W, Guan X
Received 19 August 2017
Accepted for publication 4 October 2017
Published 14 March 2018 Volume 2018:11 Pages 1403—1412
DOI https://doi.org/10.2147/OTT.S149511
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Giandomenico Roviello
Peer reviewer comments 3
Editor who approved publication: Dr Ingrid Espinoza
Introduction: FENDRR is a long non-coding RNA (lncRNA) that mediates the modification
of the epigenetic landscape of target promoters by binding to polycomb
repressive complex 2. However, the role of FENDRR in breast cancer remains
unknown.
Materials and methods: We detected the expression of FENDRR in 52 breast
cancer patients’ tissues and five breast cancer cell lines. The association
between FENDRR expression and clinicopathological features and prognosis of
breast cancer patients was also analyzed. Moreover, cell proliferation assays,
flow cytometry analysis, wound-healing assays, and transwell migration assays
were performed to detect the biological effects of FENDRR in the breast cancer
cells. A xenograft model was used to explore the role of FENDRR expression on
tumor growth.
Results: We found that FENDRR expression was lower in
breast cancer cell lines and cancerous tissues than in the adjacent normal
tissues. Low expression of FENDRR was associated with a shorter overall
survival and a shorter progression-free survival in breast cancer patients (p <0.001, p <0.001, respectively). We
found that FENDRR inhibits breast cancer cell proliferation and migration and
promotes cell apoptosis, while FENDRR knockdown promotes breast cancer cell
proliferation and migration and suppresses cell apoptosis. Finally, we also
detected that FENDRR overexpression could inhibit tumor growth in a xenograft
model.
Conclusion: Our data suggested that FENDRR inhibits breast cancer
cell proliferation, promotes cell apoptosis, and is associated with good
prognosis in breast cancer. Thus, FENDRR plays an important role in the growth
and progression of breast cancer.
Keywords: breast cancer,
FENDRR, lncRNA, prognosis, proliferation