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Authors Zhang Y, Zhang L, Zhang Q, Zhang X, Zhang T, Wang B
Received 26 October 2017
Accepted for publication 30 January 2018
Published 13 March 2018 Volume 2018:12 Pages 535—544
DOI https://doi.org/10.2147/DDDT.S155244
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Palas Chanda
Peer reviewer comments 2
Editor who approved publication: Dr Sukesh Voruganti
Background: Brucea javanica oil (BJO), a
traditional Chinese herbal medicine, has a variety of pharmacological
activities and several BJO-related patent drugs have been widely used in China.
Purpose: The objective of this study was to evaluate the gastric
therapeutic effects of self-made BJO and its pharmaceutical potential to
formulate novel BJO gastroretentive floating bead by comparing with commercial
products.
Methods: BJO was extracted from the seeds of B. javanica , and its therapeutic
effects were evaluated by comparing with commercial products in the treatment
of human gastric cancer and gastric ulcer. Furthermore, the developed
gastroretentive drug delivery system was evaluated by in vivo tests. A
high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS)
method for detecting the concentration of glycerol trioleate in the
pharmacokinetic study was applied.
Results: The antitumor activity of BJO was stronger than that of the
marketed preparation; the 50% inhibitory concentration (IC50) values of BJO extracts on HGC27, SGC7901 and BGC823 gastric carcinoma
were 0.3091, 1.736 and 2.743 μg/mL, respectively, whereas the values of marked
BJO preparation were 15.26, 32.60 and 7.456 μg/mL, respectively.
Histopathological studies demonstrated the ability of BJO to locally prevent
and treat absolute ethanol-induced gastric ulcer. Developed BJO gastroretentive
floating bead showed a satisfactory in vivo study. The highest glycerol
trioleate concentration in the stomach after taking BJO gastroretentive
floating bead was nearly two times higher when compared to the marketed BJO soft
capsule.
Conclusion: Self-made BJO has a strong therapeutic effect on the stomach, and
gastroretentive drug delivery system can be a promising approach to prolong and
enhance its therapy ability when treating gastric diseases.
Keywords: BJO, gastric tumor, gastric cancer, gastroretentive floating bead