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Authors Bai WK, Zhang W, Hu B
Received 2 January 2018
Accepted for publication 9 February 2018
Published 6 March 2018 Volume 2018:11 Pages 1267—1274
DOI https://doi.org/10.2147/OTT.S161302
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 3
Editor who approved publication: Dr Samir Farghaly
Purpose: Prostate cancer (PCa)
patients often have dendritic cell (DC) function defects, but the mechanism is
not clear. The aim of this study was to detect the effect of vascular
endothelial growth factor (VEGF) in mature DCs.
Patients and methods: In this study, we chose 30 PCa patients, 10
prostatic intraepithelial neoplasia (PIN) patients and 30 benign prostatic
hyperplasia (BPH) patients, and compared the composition of peripheral blood T
cells, the composition and function of local dendritic cells in prostate
tissue, and the density of local VEGF.
Results: The results showed that the numbers of total
DCs, mature and functional DCs, and CD4+ T cells were inhibited in PCa, and the
inhibitory effect was enhanced with increased malignancy. In addition, the
infiltration density of VEGF-positive cells was increased in PCa, and this
increase was associated with an increased malignant degree of PCa. The
inhibition of tumor immunity in patients with PCa is achieved by inhibiting the
function of dendritic cells.
Conclusion: VEGF plays an important role in the inhibition
of the maturation and function of dendritic cells, and this inhibition is
gradually increased with an increasing malignant degree of PCa.
Keywords: prostate
cancer, vascular endothelial growth factor, dendritic cell, immunology, T cell