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Authors Liu L, Liu Y, Wu M, Sun Y, Ma F
Received 14 August 2017
Accepted for publication 7 October 2017
Published 2 March 2018 Volume 2018:12 Pages 437—444
DOI https://doi.org/10.2147/DDDT.S149106
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Rammohan Devulapally
Peer reviewer comments 3
Editor who approved publication: Dr Qiongyu Guo
Background: Results
of studies on the efficacy of atorvastatin pretreatment on reducing the
prevalence of contrast-induced acute kidney injury (CIAKI) in patients
undergoing coronary angiography (CAG) or percutaneous coronary intervention
(PCI) have been controversial.
Objective: We undertook a meta-analysis to evaluate the efficacy of atorvastatin on
contrast-induced nephropathy (CIN) after CAG or PCI.
Materials and
methods: We undertook a systematic
search of electronic databases (PubMed, Embase, and the Cochrane Library) up to
June 2017. A meta-analysis was carried out including randomized controlled
trials (RCTs) that compared atorvastatin pretreatment with pretreatment with a
low-dose statin or placebo for CIAKI prevention in patients undergoing CAG. The
main endpoint was CIN prevalence.
Results: Nine RCTs were included in our meta-analysis. Atorvastatin
pretreatment reduced the prevalence of CIN significantly (odds ratio [OR] 0.46;
95% confidence interval [95% CI] 0.27–0.79; p =0.004).
The benefit of high-dose atorvastatin pretreatment was consistent when compared
with the control group (OR 0.45; 95% CI 0.21–0.95; p =0.04).
Conclusion: At high doses, atorvastatin pretreatment was associated with a
significant reduction in the prevalence of CIAKI in patients undergoing CAG.
Pretreatment with high-dose atorvastatin could be employed to prevent CIAKI.
Keywords: atorvastatin, contrast-induced acute kidney injury, coronary
angiography, percutaneous coronary intervention, contrast-induced nephropathy,
meta-analysis