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Authors Tang L, Li J, Bao M, Xiang J, Chen Y, Wang Y
Received 18 August 2017
Accepted for publication 16 January 2018
Published 1 March 2018 Volume 2018:11 Pages 1055—1066
DOI https://doi.org/10.2147/OTT.S149428
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Faris Farassati
Objective: The estrogen receptor (ER) and the human epidermal growth factor
receptor 2 (HER2) each play an important role in female cancers. This study
aimed to investigate the genetic association between three common single
nucleotide polymorphisms (SNPs) and the risk of ovarian cancer. The SNPs
investigated in this study were ESR2 rs1271572 and rs3020450 and HER2
rs1801200.
Methods: In this study, databases were electronically
searched in a meta-analysis. Databases used were PubMed, Embase, China National
Knowledge Infrastructure (CNKI), Wanfang and Cochrane library. Case–control
studies on the association between ESR2 and HER2 polymorphisms were selected
according to inclusion and exclusion standard. Articles were evaluated for
quality, and data were extracted.
Results: A total of 13 articles with 5,461 cases and
7,603 controls were included in this meta-analysis. The recessive model of ESR2
rs1271572 was shown to be significantly associated with the risk of ovarian
cancer (p = 0.008, odds ratio [OR]
[95% confidence interval {CI}] = 1.13 [1.03, 1.24]), and this significant
association still existed in a subgroup analysis stratified by ethnicity
(Asian: p = 0.04, OR [95% CI] = 1.92
[1.04, 3.56]; Caucasian: p = 0.02, OR
[95% CI] = 1.12 [1.02, 1.23]). In addition, the distribution of the dominant
model of ESR2 rs3020450 was significantly different in the total group (p = 0.02, OR [95% CI] = 0.71
[0.53, 0.95]) and the Caucasian subgroup (p = 0.02, OR
[95% CI] = 0.67 [0.48, 0.94]). Furthermore, no significant association between
allelic, dominant, codominant and recessive models of HER2 rs1801200 (V655I)
and ovarian cancer was found (p > 0.05).
Conclusion: The recessive model of ESR2 rs1271572 and the
dominant model of ESR2 rs3020450 might be susceptible factors for ovarian
cancer.
Keywords: ESR2, ovarian
cancer, HER2, meta-analysis