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Authors Hu XW, Wang HB, Tu YH, Fei MD, Yin MM, Fei GH, Yu YQ
Received 20 July 2017
Accepted for publication 1 December 2017
Published 7 February 2018 Volume 2018:13 Pages 519—528
DOI https://doi.org/10.2147/COPD.S146870
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Charles Downs
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Chunxue Bai
Background and
objectives: Cognitive impairment is a
common extrapulmonary comorbidity in COPD patients. The default mode network
(DMN) plays a critical role in maintaining the normal activities of humans, and
its function can be evaluated by resting state functional magnetic resonance
imaging. The aim of this study was to investigate the correlations between
cognition and function changes of the DMN in COPD patients.
Methods: One hundred and thirteen eligible participants
including 30 control subjects and 83 COPD patients matched for demographic
characteristics were recruited. All participants performed cognitive function
tests and underwent resting state functional magnetic resonance imaging.
Results: The total cognitive function scores of COPD
patients were significantly different from those of control subjects (P <0.05) and worsened with the
degree of airflow obstruction. The activated brain regions in the DMN of COPD
patients were less than those of normal controls. Six activated brain regions
in the DMN were found to develop significantly different functional
connectivity (FC) values among the subjects. Meanwhile, the FC values of the
left posterior cingulate cortex and left hippocampus correlated well with
cognitive functions and pulmonary function.
Conclusion: COPD patients have cognitive impairments that
correlate well with disease severity. FC changes in activated brain regions in
the DMN may predict cognitive impairment, and the left posterior cingulate
cortex and left hippocampus may be important brain regions related to cognitive
impairment in COPD patients.
Keywords: chronic
obstructive pulmonary disease, cognitive function, resting state functional
magnetic resonance imaging, default mode network