论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Yang W, Gu L, Yang C, Liu T
Received 15 October 2017
Accepted for publication 13 December 2017
Published 8 February 2018 Volume 2018:11 Pages 743—749
DOI https://doi.org/10.2147/OTT.S154188
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 3
Editor who approved publication: Dr Tohru Yamada
Objective: Nemo-like
kinase (NLK) has been reported to play different roles in tumors. However, the
role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this
study, we explored the clinical significance including survival of NLK protein
expression in CSCCs.
Patients and
methods: Immunohistochemical method was
performed using tissues from 130 patients with CSCC. The associations
between NLK expression and the clinicopathological factors and prognosis of
CSCCs were evaluated. Statistical analyses were performed using the chi-square
test, the multivariate Cox proportional hazard model, and the Kaplan–Meier
method.
Results: Immunohistochemical staining analysis showed that NLK was localized
predominately in the nucleus of the tumor cells, and increased NLK expression
was detected in 71 (54.6%) of 130 patients. NLK overexpression significantly
correlated with higher histological grade (P =0.001),
vascular/lymphatic invasion (P =0.010), lymph
node metastasis (P =0.012), and recurrence (P =0.022). Patients with elevated
NLK expression had poorer overall survival (OS) and disease-free survival (DFS)
(P =0.006 and P =0.004, respectively) compared
with patients with decreased NLK expression. Multivariate Cox analysis
demonstrated that NLK overexpression was an independent factor for OS and DFS (P =0.034 and P =0.025, respectively).
Conclusion: NLK may be a valuable biomarker for predicting the prognosis of
CSCC patients and may serve as a potential target for cancer therapy.
Keywords: Nemo-like kinase, cervical squamous cell carcinoma, prognosis,
progression, lymph node metastasis, survival, biomarker