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Authors Wu J, Guo HX, Liu X, Li M, Cao YJ, Qu XY, Zhou H, Weng LQ
Received 14 July 2017
Accepted for publication 22 December 2017
Published 2 February 2018 Volume 2018:14 Pages 219—224
DOI https://doi.org/10.2147/TCRM.S146426
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Hoa Le
Peer reviewer comments 2
Editor who approved publication: Professor Deyun Wang
Background and
purpose: Percutaneous autologous bone marrow
transplantation (PABMT) is a minimally invasive therapeutic strategy for the
treatment of delayed bone union in adults, which has been confirmed by many
studies. However, there is no report on PABMT application in pediatric
orthopedic surgery. The aim of this article was to analyze the therapeutic
effect of PABMT in children with delayed union of limb bone and its influence
in relation to delayed bone union therapy, transplantation period, patients’
sex, fracture location, and fracture fixation.
Methods: In this study, 53 patients (aged 3–16 years, with an average
age of 6.7 years) with delayed union of long bone (20 femurs, 12 tibiae,
10 humeri, 5 radiuses, 5 ulnas, and 1 fibula) were treated using PABMT.
Clinical examination and X-ray were integrated to evaluate the therapeutic
effect.
Results: All 53 patients were followed up for 2–6 years (average time,
3.5 years). Of the 53 patients, 47 (88.7%) were healed, whereas the other
6 (11.3%) were not, and were subsequently treated by autologous bone grafting.
In 30 patients who received their first PABMT treatment 6–8 months after
fixation, the clinical cure rate, operation times, and healing time were 83.3%,
5.8±0.5 months, and 2.5±0.6, respectively. In the other 23 patients, whose
first PABMT treatments were started within 4 to 6 months after
fixation, the clinical cure rate, operation times, and healing time were 95.7%
(P =0.167), 3.2±0.3 months (P =0.001), and 1.3±0.6 (P =0.001), respectively. The
patients’ sex, fracture location, and fracture fixation did not have
statistical influence on the clinical efficacy.
Conclusion: PABMT is a minimally invasive and effective strategy for the
treatment of delayed union of limb bone in children. The early surgical
treatment facilitates the fracture healing, reduces the number of transplantation,
and shortens the course of treatment.
Keywords: fracture, minimally invasive, medulla ossium, mesenchymal stem