论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Chen D, Dai C, Kadeer X, Mao R, Chen YB, Chen C
Received 20 September 2017
Accepted for publication 14 November 2017
Published 31 January 2018 Volume 2018:14 Pages 203—211
DOI https://doi.org/10.2147/TCRM.S152127
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Hoa Le
Peer reviewer comments 3
Editor who approved publication: Professor Deyun Wang
Abstract: Ground-glass
nodule (GGN) is defined as a nodular shadow with ground-glass opacity that is
generally associated with the early-stage lung adenocarcinoma. Nowadays, GGNs
of the lung are increasingly detected with thin-section computed tomography
scan. GGNs are categorized as pure GGNs and mixed GGNs according to the images
from a high-resolution computed tomography. Meanwhile, it is routine to divide
GGNs into different categories according to the number, solitary, or multiple,
the management of which there is very different. A great number of studies have
been conducted to analyze the different characteristics of GGNs in various
aspects ranging from radiology, pathology, and surgery to molecular biology.
However, plenty of problems still remain unsolved, ranging from the
preoperative localization to intraoperative surgical resection procedure, the
lymphadenectomy, and sampling of lymph nodes, as well as the accuracy of frozen
sections. There has been a large volume of updated published information
summarizing recently emerging and rapidly progressing aspects of surgical
treatment of solitary and multiple GGNs with the unsolved problems mentioned
above. However, there have been few specific reviews of surgical treatment of
GGNs so far. This review presents a timely outline of advances in relevant
experience and controversies of GGNs for a better understanding of this kind of
lesion.
Keywords: ground-glass nodules, early stage lung adenocarcinoma, therapeutic
strategy, preoperative localization, surgical pathology, lymph node management