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Authors Jiang B, Zhang XP, Chen MF, Wang Z, Zhao MX, Chen BH, Li HL
Received 29 August 2017
Accepted for publication 16 November 2017
Published 26 January 2018 Volume 2018:13 Pages 159—163
DOI https://doi.org/10.2147/CIA.S150283
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Dr Wu
Background: The purpose of this study was to analyze the disease distribution of
patients in the late stage of dementia through a cross-sectional investigation
and to clarify the association between apolipoprotein E (APOE ) genotypes and the serum
levels of total cholesterol, total triglycerides, and blood glucose in the
late-stage Alzheimer’s disease (AD) patients.
Methods: Patients who were in the late stage of dementia in a mental health
center were enrolled in this study. A broad battery of neuropsychological tests
and neuroimaging was applied to make the diagnosis. The APOE genotype was determined
by the multiplex amplification refractory mutation system polymerase chain
reaction. The association between APOE genotype
and the blood level of biochemical parameters was studied.
Results: A total of 155 patients were enrolled in this study. The majority
of patients had AD (67.8%), followed by vascular dementia (15.5%), mixed
dementia (9%), and others (7.7%). The APOE ε4 allele
frequency was significantly different in the different groups. The serum level
of total cholesterol (TC) in APOE ε4 carriers
was higher than in non-carriers (P <0.05). No
statistically significant differences were found in the blood glucose and
triglycerides (TG) levels between these two groups.
Conclusion: To our knowledge, this is the first paper to study the
characteristics of late-stage dementia in hospital patients in Southeast China.
We found that the disease distribution was quite consistent with previous
prevalence studies. Moreover, we found that the serum level of TC was higher
in APOE ε4 carriers group.
However, no association was found between the APOE ε4 allele
and serum levels of glucose, TC and TG in the late stage of AD.
Keywords: Alzheimer’s disease, APOE , glucose,
cholesterol, triglycerides