论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Li Y, Wang P, Li L, Wang F, Liu Y
Received 15 November 2017
Accepted for publication 8 December 2017
Published 23 January 2018 Volume 2018:14 Pages 157—165
DOI https://doi.org/10.2147/TCRM.S157085
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Hoa Le
Peer reviewer comments 2
Editor who approved publication: Professor Deyun Wang
Objective: Polymyositis and dermatomyositis (PM/DM) have been implicated in the
development of venous thromboembolism (VTE). Previous studies investigating the
association between PM/DM and VTE risk had yielded inconsistent findings. The
aim of this study was to precisely estimate this association by meta-analysis
of all available publications.
Methods: Two investigators independently performed a comprehensive
literature search in databases of PubMed, Embase, and the Cochrane Library
for eligible studies. The strength for the association was weighed by pooled
odds ratios (ORs) with 95% confidence intervals (95% CIs). Stratified analysis
and sensitivity analysis were performed for further analysis.
Results: Six studies including 9,045 patients with PM/DM were analyzed. The
pooled OR suggested that inflammatory myositis was associated with increased
risk of VTE (OR =4.31, 95% CI: 2.55–7.29, P <0.001).
Besides, significantly elevated risk of VTE was related with PM and DM,
respectively (for PM: OR =6.87, 95% CI: 4.12–11.46, P <0.001; for DM: OR =11.59, 95%
CI: 6.54–20.55, P <0.001). In
addition, inflammatory myositis could increase the risk of DVT (OR =4.85, 95%
CI: 1.38–17.12, P <0.05) and PE
(OR =4.74, 95% CI: 2.18–10.30, P <0.05).
Sensitivity analysis did not materially alter the pooled results.
Conclusion: Our study shows strong evidence that patients with inflammatory myositis
have an increased risk of VTE.
Keywords: polymyositis, dermatomyositis, venous thromboembolism, deep venous
thrombosis, pulmonary embolism