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Authors Zhang M, Tang J, Yin J, Wang X, Feng X, Yang X, Shan H, Zhang Q, Zhang J, Li Y
Received 29 September 2017
Accepted for publication 14 December 2017
Published 19 January 2018 Volume 2018:13 Pages 357—363
DOI https://doi.org/10.2147/COPD.S152898
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Chunxue Bai
Background: Cyclophilin
A (CyPA) is a secreted molecule that is regulated by inflammatory stimuli.
Although inflammation has an important role in the pathogenesis of chronic
obstructive pulmonary disease (COPD), little is known regarding the
relationship between serum CyPA and COPD.
Methods: Ninety-three COPD patients with acute exacerbation were enrolled
in the study and were reassessed during the convalescence phase. Eighty-eight
controls were matched for age, gender, body mass index, smoking index and comorbidity.
The basic clinical information and pulmonary function of all participants were
collected. Serum levels of CyPA and other inflammation indexes were further
measured.
Results: Serum CyPA was significantly increased in convalescent COPD
patients compared to healthy controls, and further elevated in COPD patients
with acute exacerbation. Serum CyPA positively correlated with serum
interleukin-6, matrix metalloproteinase-9 and high-sensitivity C-reactive
protein in both the exacerbation and convalescence phases of COPD. Furthermore,
it negatively correlated with percent value of forced expiratory volume in 1
second (FEV1%) predicted and FEV1/forced vital
capacity in convalescent COPD patients.
Conclusion: These results suggest that serum CyPA can be used as a potential
inflammatory biomarker for COPD and assessment of serum CyPA may reflect the
severity of inflammation in COPD.
Keywords: cyclophilin A, chronic obstructive pulmonary disease,
exacerbation, convalescence, inflammation