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已发表论文
食管癌中血清 C 反应蛋白的预后作用：系统回顾和综合分析
Authors Huang Y, Feng JF, Liu JS, Chen QX
Published Date January 2015 Volume 2015:11 Pages 89—94
DOI http://dx.doi.org/10.2147/TCRM.S70954
Received 11 July 2014, Accepted 11 September 2014, Published 14 January 2015
Background: Recent studies have shown that C-reactive protein (CRP) is a useful
predictive factor in several cancers; however, its role in esophageal cancer
(EC) is controversial.
Methods: A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.
Results: A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25–1.57, I 2=81.3%, P <0.0001). Subgroup analyses were performed in further investigations. When the patients were segregated according to treatment, pathological type, and cut-off level, high levels of serum CRP were found to be significantly correlated with OS.
Conclusion: Our meta-analysis revealed that high levels of serum CRP were significantly associated with poor OS in patients with EC.
Keywords: CRP, esophageal cancer, meta-analysis
Methods: A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.
Results: A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25–1.57, I 2=81.3%, P <0.0001). Subgroup analyses were performed in further investigations. When the patients were segregated according to treatment, pathological type, and cut-off level, high levels of serum CRP were found to be significantly correlated with OS.
Conclusion: Our meta-analysis revealed that high levels of serum CRP were significantly associated with poor OS in patients with EC.
Keywords: CRP, esophageal cancer, meta-analysis
