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已发表论文
UHRF2 在肝内胆管癌中的高表达及其临床意义
Authors Peng R, Huang X, Zhang C, Yang X, Xu Y, Bai D
Received 17 August 2017
Accepted for publication 5 November 2017
Published 11 December 2017 Volume 2017:10 Pages 5863—5872
DOI https://doi.org/10.2147/OTT.S149361
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Giandomenico Roviello
Peer reviewer comments 2
Editor who approved publication: Dr Jianmin Xu
Abstract: Ubiquitin-like with
PHD and ring finger domains 2 (UHRF2) has been implicated in tumorigenesis.
However, its roles in intrahepatic cholangiocarcinoma (ICC) are still unclear.
In this study, UHRF2 expression was analyzed in several kinds of cancers by
referring to public Oncomine database, and the levels of UHRF2 mRNA and protein
were determined in ICC cells and tissues. Then, the roles of UHRF2 in ICC were
investigated by UHRF2 interference. Moreover, the relationship between UHRF2
and E-cadherin expression was examined in ICC cells and samples. Finally, the
prognostic role of UHRF2 in ICC was analyzed in 139 ICC patients by Cox
regression and Kaplan–Meier methods. We found UHRF2 was overexpressed in
multiple human cancers, as well as in ICC, and the invasion, migration,
proliferation, and antiapoptosis of ICC cells were inhibited by UHRF2
interference. Moreover, the epithelial–mesenchymal transition-related marker
E-cadherin was upregulated in ICC cells which was influenced by UHRF2
expression. Clinically, UHRF2 expression was positively associated with
microvascular invasion and lymphatic metastasis of ICC, and patients in the
UHRF2high group had much lower overall survival and
higher recurrence rates than patients in the UHRF2low group.
A multivariate analysis revealed that UHRF2 overexpression was a new prognostic
marker for ICC. Thus, our results indicated that high level of UHRF2 might be a
novel predictor for the prognosis of ICC.
Keywords: ICC, UHRF2, E-cadherin, prognosis, biomarker
Keywords: ICC, UHRF2, E-cadherin, prognosis, biomarker
