论文已发表
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IF 收录期刊
Authors Zhu R, Tian Y
Received 21 August 2017
Accepted for publication 5 October 2017
Published 6 December 2017 Volume 2017:11 Pages 3481—3489
DOI https://doi.org/10.2147/DDDT.S149620
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Dr Anastasios Lymperopoulos
Abstract: The aim of this study is to develop a novel RGD and TAT
co-modified docetaxel (DTX)-loaded liposome (LP) by the emulsification-solvent
evaporation method. The prepared LPs were found to be in the size of 100 nm–110
nm. The transmission electron microscope photomicrographs were smooth,
sub-spherical in shape, and aggregated to form small clusters. The DTX
cumulative release from TAT and RGD co-modified LPs was significantly higher
than that from other LPs due to decreased diffusion distance. Results of cell
uptake showed that surface modification could indicate when cell
internalization was changed and more drugs entered the cells successfully.
Surprisingly, TAT and RGD co-modified DTX-LPs demonstrated a superior
antiproliferative effect on A549 cells with a possible mechanism that
suppressed the multidrug resistance phenomenon and exhibited a clear
synergistic effect. In antitumor study, our results indicated that the form of
TAT and RGD co-modified LPs had a better antitumor effect in vivo than the
other formulations.
Keywords: RGD, TAT,
liposome, cell uptake, cytotoxicity, antitumor