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已发表论文
纳米粒子的主要参数对其理化性质的影响，及纳米药物递送系统在靶向化疗中的应用
Authors Zhang J, Tang H, Liu Z, Chen B
Received 4 August 2017
Accepted for publication 14 October 2017
Published 28 November 2017 Volume 2017:12 Pages 8483—8493
DOI https://doi.org/10.2147/IJN.S148359
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Abstract: Chemotherapy is
still one of the main cancer therapy treatments, but the curative effect of
chemotherapy is relatively low, as such the development of a new cancer
treatment is highly desirable. The gradual maturation of nanotechnology
provides an innovative perspective not only for cancer therapy but also for
many other applications. There are a diverse variety of nanoparticles
available, and choosing the appropriate carriers according to the demand is the
key issue. The performance of nanoparticles is affected by many parameters,
mainly size, shape, surface charge, and toxicity. Using nanoparticles as the
carriers to realize passive targeting and active targeting can improve the
efficacy of chemotherapy drugs significantly, reduce the mortality rate of
cancer patients, and improve the quality of life of patients. In recent years,
there has been extensive research on nanocarriers. In this review, the effects
of several major parameters of nanoparticles on their physical and chemical
properties are reviewed, and then the recent progress in the application of
several commonly used nanoparticles is presented.
Keywords: nanocarrier, parameters, chemotherapy, drug targeting delivery
Keywords: nanocarrier, parameters, chemotherapy, drug targeting delivery
