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Authors Qu Y, Wang Z, Zhou H, Kang M, Dong R, Zhao J
Received 13 June 2017
Accepted for publication 19 August 2017
Published 24 November 2017 Volume 2017:12 Pages 8459—8469
DOI https://doi.org/10.2147/IJN.S143824
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Thiruganesh Ramasamy
Peer reviewer comments 3
Editor who approved publication: Professor Dongwoo Khang
Abstract: Degenerative lumbar disease (DLD) is a significant issue for public
health. Posterior lumbar intervertebral fusion with cages (PLIFC) has
high-level fusion rate and realignment on DLD. However, there are some
complications following the surgery. Alginate oligosaccharides (AOS) have
antioxidant and anti-inflammatory activities and may be suitable for infection
therapy. MiR-155 is a biomarker associated with inflammatory and oxidative
stress. AOS may promote PLIFC therapy by regulating miR-155. Pluronic nanoparticles
and oligosaccharide nanomedicine of alginate sodium (ONAS) were prepared with
ampicillin at size <200 nm. Ninety-six DLD osteoporosis patients
received PLIFC and were evenly assigned into ONAS group (OG, oral
administration of 100 mg ONAS daily) and control group (PG, 100 mg
pluronic nanoparticles). Serum miR-155 level was measured by real-time
quantitative PCR. The levels of superoxide dismutase (SOD), glutathione (GSH),
aspartate aminotransaminase (AST), alanine aminotransferase (ALT), interleukin-1β
(IL-1β), and interleukin-1 receptor antagonist (IL-1ra) were measured. Weighted
mean difference (WMD), relative risk (RR), complications, surgery infection
rate, fusion rate, and Japanese Orthopaedic Association (JOA) scores were used
to evaluate therapeutic efficacy. After 1-month therapy, infection rates and
side effects were lower in OG than those in PG (RR =0.64, 95% confidence
interval [CI] [0.48, 0.84], P =0.001). The
fusion rates were higher in OG than in PG (WMD =21.96, 95% CI [–0.24,
37.62], P =0.021). The JOA scores were
higher in OG than in PG (RR =0.52, 95% CI [0.33, 0.84], P =0.007), and no significant
difference was found for the visual analog scale and Oswestry Disability Index.
Serum levels of miR-155, ALT, AST, and IL-1β were lower while SOD, GSH, and
IL-1ra were higher in OG than in PG. MiR-155 mimic increased the levels of ALT,
AST, and IL-1β and reduced the levels of SOD, GSH, and IL-1ra. In contrast,
miR-155 inhibitor had reverse results. Therefore, ONAS has better improvement
in complications and therapeutic effects on DLD by regulating serum miR-155.
Keywords: alginate oligosaccharide, antioxidant, anti-inflammatory, fusion
rate, infection rate, Japanese Orthopaedic Association,
Oswestry Disability Index