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已发表论文
神经性厌食症女性脑白质微结构改变：弥散张量成像研究
Authors Hu SH, Feng H, Xu TT, Zhang HR, Zhao ZY, Lai JB, Xu DR, Xu Y
Received 27 June 2017
Accepted for publication 10 October 2017
Published 21 November 2017 Volume 2017:13 Pages 2829—2836
DOI https://doi.org/10.2147/NDT.S144972
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Prof. Dr. Roumen Kirov
Peer reviewer comments 2
Editor who approved publication: Professor Wai Kwong Tang
Objective: Structural studies
have reported anorexia nervosa (AN) patients with abnormal gray matter in
several brain regions and dysfunction in some connected neural circuits.
However, the role of white matter (WM) in AN patients has rarely been
investigated. The present study aimed to assess alterations in WM
microstructure of the entire brain in females with AN using a voxel-based
method on diffusion tensor imaging (DTI) data.
Materials and methods: The study enrolled 8 female patients with AN and 14 age-matched females as controls (CW). The DTI data was collected from each subject to calculate the fractional anisotropy (FA) maps of the whole brain by the DTI-Studio software. Subsequently, a 2-sample t -test (P <0.05, corrected) was performed to detect the difference in FA maps of AN and CW group, and a Pearson’s correlation analyzed the relationship between mean FA value of brain regions and body mass index (BMI).
Results: Compared with CW, AN patients revealed a significant decrease in FA maps in the left superior frontal gyrus, medial frontal gyrus, anterior cingulate cortex, middle frontal gyrus, inferior frontal gyrus, thalamus, and bilateral insula. Moreover, significantly positive correlations were established between the mean FA value of the left inferior frontal gyrus, insula as well as thalamus and BMI in AN patients.
Conclusions: Our findings supported the presence of WM abnormality in patients with AN. The significant differences of FA maps, in patients with AN, were associated with their aberrant BMI. The results further improved our understanding of the pathophysiological mechanisms underlying AN.
Keywords: anorexia nervosa, magnetic resonance imaging, diffusion tensor imaging, white matter
Materials and methods: The study enrolled 8 female patients with AN and 14 age-matched females as controls (CW). The DTI data was collected from each subject to calculate the fractional anisotropy (FA) maps of the whole brain by the DTI-Studio software. Subsequently, a 2-sample t -test (P <0.05, corrected) was performed to detect the difference in FA maps of AN and CW group, and a Pearson’s correlation analyzed the relationship between mean FA value of brain regions and body mass index (BMI).
Results: Compared with CW, AN patients revealed a significant decrease in FA maps in the left superior frontal gyrus, medial frontal gyrus, anterior cingulate cortex, middle frontal gyrus, inferior frontal gyrus, thalamus, and bilateral insula. Moreover, significantly positive correlations were established between the mean FA value of the left inferior frontal gyrus, insula as well as thalamus and BMI in AN patients.
Conclusions: Our findings supported the presence of WM abnormality in patients with AN. The significant differences of FA maps, in patients with AN, were associated with their aberrant BMI. The results further improved our understanding of the pathophysiological mechanisms underlying AN.
Keywords: anorexia nervosa, magnetic resonance imaging, diffusion tensor imaging, white matter
