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已发表论文
IGF2BP2 和 PPARG 多态性与中国东部地区汉族人群食管鳞状细胞癌易感性之间关系的研究
Authors Qiu H, Wang Y, Kang M, Ding H, Liu C, Tang W, Xiao Z, Chen Y
Received 7 July 2017
Accepted for publication 16 October 2017
Published 21 November 2017 Volume 2017:10 Pages 5525—5532
DOI https://doi.org/10.2147/OTT.S145776
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Jianmin Xu
Abstract: The aim of this
case–control study was to assess whether PPARG and IGF2BP2 polymorphisms confer
susceptibility to esophageal squamous-cell carcinoma (ESCC). A total of 507
patients pathologically confirmed for ESCC and 1,496 age-, sex-, and
residence-matched healthy individuals were enrolled. The PPARG rs1801282 C>G and
rs3856806 C>T and IGF2BP2 rs1470579
A>C and rs4402960 G>T polymorphisms were selected and genotyped by
SNPscan genotyping assays. Multivariable logistic analysis suggested that
the PPARG rs3856806 C>T
polymorphism might increase the risk of ESCC. In different stratified analyses,
there were significant associations between PPARG rs3856806
C>T and risk of ESCC in female, never-smoking, drinking, and never-drinking
subgroups. In addition, we also found that PPARG rs1801282
C>G increased ESCC risk in the never-smoking subgroup. There was significant
difference in Crs1470579Grs4402960Crs1801282Crs3856806-haplotype distribution among ESCC cases and
control subjects. In conclusion, our findings highlight that PPARG rs1801282 C>G and
rs3856806 C>T polymorphisms are candidates for susceptibility to ESCC in the
eastern Chinese Han population. The Crs1470579Grs4402960Crs1801282Crs3856806 haplotype is associated with
susceptibility to ESCC.
Keywords: PPARG , IGF2BP2 , polymorphism, risk, ESCC
Keywords: PPARG , IGF2BP2 , polymorphism, risk, ESCC
