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已发表论文
一种用于加强癌症治疗和克服治疗耐受性的基于纳米脂质体的光控释药型药物递送系统
Authors Shi J, Su Y, Liu W, Chang J, Zhang Z
Received 12 June 2017
Accepted for publication 3 August 2017
Published 14 November 2017 Volume 2017:12 Pages 8257—8275
DOI https://doi.org/10.2147/IJN.S143776
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Thiruganesh Ramasamy
Peer reviewer comments 4
Editor who approved publication: Dr Linlin Sun
Abstract: Recently,
stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution
bring many benefits to cancer treatment. However, cancer cells always develop
ways to resist and evade treatment, ultimately limit the treatment efficacy of
the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart
light-induced cytotoxicity and reversal of drug resistance in synchrony with a
photoinitiated and rapid release of antitumor drug. The PNLs consist of a
nanoliposome doped with a photosensitizer (hematoporphyrin monomethyl ether
[HMME]) in the lipid bilayer and an antitumor drug doxorubicin (DOX)
encapsulated inside. PNLs have several distinctive capabilities: 1) carrying
high loadings of DOX and HMME and releasing the payloads in a photo-cleavage
manner with high spatial/temporal resolution at the site of actions via photocatalysis;
2) reducing drug efflux in MCF-7/multidrug resistance cells via decreasing the
level of P-glycoprotein induced by photodynamic therapy (PDT); 3) accumulating
in tumor site taking advantage of the enhanced permeability and retention
effect; and 4) combining effective chemotherapy and PDT to exert much enhanced
anticancer effect and achieving significant tumor regression in a
drug-resistant tumor model with little side effects.
Keywords: drug delivery, photo-responsive release, photodynamic-chemotherapy, photocatalysis, multidrug resistance
Keywords: drug delivery, photo-responsive release, photodynamic-chemotherapy, photocatalysis, multidrug resistance
