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已发表论文
载脂蛋白 E 基因多态性与轻度认知功能障碍之间的关联：一项荟萃分析
Authors Jiang Y, He T, Deng W, Sun P
Received 10 June 2017
Accepted for publication 8 October 2017
Published 13 November 2017 Volume 2017:12 Pages 1941—1949
DOI https://doi.org/10.2147/CIA.S143632
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Professor Zhi-Ying Wu
Abstract: A number of published
case–control studies reported that the apolipoprotein E (ApoE) gene
polymorphism was associated with the mild cognitive impairment (MCI). However,
previous reports still remain conflicting. To estimate the association between
ApoE polymorphism and MCI susceptibility, we searched the electronic databases
including PubMed, Wanfang, CNKI (China National Knowledge Infrastructure), VIP,
and EMBASE to retrieve all available studies. A total of 18 studies with 2,004
cases and 3,705 controls were included in this meta-analysis. The pooled
analysis based on selected studies showed that statistically significant risk
association was found between ApoE gene polymorphism and MCI in overall
population (ε 4 vs ε 3:
odds ratio [OR] =2.38, 95% confidence interval [CI]: 2.11–2.68; ε 4/ε 4
vs ε 3/ε 3:
OR =4.45, 95% CI: 3.06–6.48; ε 2/ε 4 vs ε 3/ε 3:
OR =2.57, 95% CI: 1.77–3.73; ε 3/ε 4 vs ε 3/ε 3:
OR =2.31, 95% CI: 1.99–2.69). However, no significant association was detected
in two genetic models: ε 2
versus ε 3 (OR =0.90, 95% CI: 0.77–1.05)
and ε 2/ε 2
versus ε 3/ε 3
(OR =0.91, 95% CI: 0.50–1.65). Furthermore, ApoE ε 2/ε 3
genotype provided a slight protection for MCI in overall population (ε 2/ε 3
vs ε 3/ε 3: OR =0.80, 95% CI: 0.66–0.97). In the stratified analysis based on
ethnicity, similar results were also observed in Chinese population
(significant risk: ε 4 vs ε 3: OR =2.52, 95% CI: 2.19–2.90; ε 4/ε 4
vs ε 3/ε 3:
OR =5.45, 95% CI: 3.41–8.70; ε 2/ε 4 vs ε 3/ε 3:
OR =2.59, 95% CI: 1.74–3.86; ε 3/ε 4 vs ε 3/ε 3:
OR =2.34, 95% CI: 1.97–2.79; slight protection: ε 2/ε 3
vs ε 3/ε 3:
OR =0.79, 95% CI: 0.64–0.98; no association: ε 2
vs ε 3: OR =0.92, 95% CI: 0.78–1.09;
and ε 2/ε 2
vs ε 3/ε 3:
OR =1.04, 95% CI: 0.55–1.99). In summary, this meta-analysis of 5,709 subjects
suggested that ApoE ε 4 allele was
associated with an increased risk of MCI. In addition, ApoE ε 2/ε 3
genotype provided a slight protection for MCI.
Keywords: mild cognitive impairment, apolipoprotein E, polymorphism, meta-analysis
Keywords: mild cognitive impairment, apolipoprotein E, polymorphism, meta-analysis
