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已发表论文
Reversal of cognitive impairment in a hypotensive elderly population using a passive exercise intervention
Authors McLeod KJ, Stromhaug A
Received 1 August 2017
Accepted for publication 12 October 2017
Published 7 November 2017 Volume 2017:12 Pages 1859—1866
DOI https://doi.org/10.2147/CIA.S147959
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Richard Walker
Background: Cognitive
decline in the elderly is strongly associated with cerebral hypoperfusion, a
condition that can be reversed with exercise. Adhering to a traditional
exercise regimen, however, is challenging for this population.
Objective: In a pilot clinical study, we evaluated the ability of a “passive” exercise regimen (noninvasive calf muscle pump stimulation) to normalize blood pressure in a chronically hypotensive elderly population and enhance cognitive function.
Participants and methods: Ten elderly (82.5±7.5 years) men and women volunteers, residing in a senior living facility in upstate New York, were divided into control (N=5) and intervention (N=5) groups based on initial diastolic blood pressure (DBP); participants with initial DBP <65 mmHg became intervention participants, and those with initial DBP >65 mmHg enrolled in the control group. Body mass, blood pressure, and executive function (using incongruent Stroop and Trailmaking B test) were evaluated weekly for 4 months.
Results: At initiation of the study, time to complete the executive function tests in the hypotensive group was almost twice that of the control group. Daily calf muscle pump stimulation (passive exercise) for 1 hour/day, or less, was found to be sufficient to normalize DBP and significantly improve performance on the executive function tests.
Keywords: cognitive impairment, chronic hypotension, soleus stimulation, executive function
Objective: In a pilot clinical study, we evaluated the ability of a “passive” exercise regimen (noninvasive calf muscle pump stimulation) to normalize blood pressure in a chronically hypotensive elderly population and enhance cognitive function.
Participants and methods: Ten elderly (82.5±7.5 years) men and women volunteers, residing in a senior living facility in upstate New York, were divided into control (N=5) and intervention (N=5) groups based on initial diastolic blood pressure (DBP); participants with initial DBP <65 mmHg became intervention participants, and those with initial DBP >65 mmHg enrolled in the control group. Body mass, blood pressure, and executive function (using incongruent Stroop and Trailmaking B test) were evaluated weekly for 4 months.
Results: At initiation of the study, time to complete the executive function tests in the hypotensive group was almost twice that of the control group. Daily calf muscle pump stimulation (passive exercise) for 1 hour/day, or less, was found to be sufficient to normalize DBP and significantly improve performance on the executive function tests.
Keywords: cognitive impairment, chronic hypotension, soleus stimulation, executive function
