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已发表论文
Nifuratel，一种新的 STAT3 抑制剂，具有对付人胃癌细胞的有效活性
Authors Zheng HL, Hong H, Zhang LL, Cai X, Hu M, Cai YP, Zhou B, Lin JY, Zhao CG, Hu WL
Received 12 July 2017
Accepted for publication 25 September 2017
Published 1 November 2017 Volume 2017:9 Pages 565—572
DOI https://doi.org/10.2147/CMAR.S146173
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Professor Kenan Onel
Abstract: Activation
of the signal transducer and activator of transcription 3 (STAT3) is observed
in multiple cancer types, including gastric cancer, and represents a potential
drug target for chemotherapy. Currently, clinically available small-molecule
inhibitors targeting STAT3 are lacking. Here, we report that nifuratel, an
antiprotozoal and antifungal drug, is a potent inhibitor of STAT3. We found
that nifuratel significantly suppressed proliferation and induced apoptosis of
gastric cancer cells. Studies of the mechanism of action of nifuratel indicated
that it acts by inhibiting the constitutive and interleukin-6-induced STAT3
activation. Taken together, our findings demonstrate that nifuratel may be a
novel, clinically accessible STAT3 inhibitor in gastric cancer cells.
Keywords: nifuratel, STAT3, gastric cancer, inhibitor, drug
Keywords: nifuratel, STAT3, gastric cancer, inhibitor, drug
