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已发表论文
简单的还原敏感胶束用于紫杉醇 (Paclitaxel) 和达沙替尼 (dasatinib) 共同递送以克服肿瘤多药耐药性
Authors Li J, Xu R, Lu X, He J, Jin S
Received 3 August 2017
Accepted for publication 14 September 2017
Published 1 November 2017 Volume 2017:12 Pages 8043—8056
DOI https://doi.org/10.2147/IJN.S148273
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Govarthanan Muthusamy
Peer reviewer comments 4
Editor who approved publication: Professor Dongwoo Khang
Abstract: Multidrug
resistance (MDR) is one of the major obstacles in successful chemotherapy. The
combination of chemotherapy drugs and multidrug-resistant reversing agents for
treating MDR tumor is a good strategy to overcome MDR. In this work, we
prepared the simple redox-responsive micelles based on mPEG-SS-C18 as a co-delivery system to load the
paclitaxel (PTX) and dasatinib (DAS) for treatment of MCF-7/ADR cells. The
co-loaded micelles had a good dispersity and a spherical shape with a uniform
size distribution, and they could quickly disassemble and rapidly release drugs
under the reduction environment. Compared with MCF-7 cells, the DAS and PTX
co-loaded redox-sensitive micelle (SS-PDNPs) showed stronger cytotoxicity and a
more improving intracellular drug concentration than other drug formulations in
MCF-7/ADR cells. In summary, the results suggested that the simple co-delivery
micelles of PTX and DAS possessed significant potential to overcome drug
resistance in cancer therapy.
Keywords: redox responsive, overcoming multidrug resistant, co-delivery, paclitaxel, dasatinib
Keywords: redox responsive, overcoming multidrug resistant, co-delivery, paclitaxel, dasatinib
