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Authors Liu J, Kang Y, Yin S, Song B, Wei L, Chen L, Shao L
Received 14 August 2017
Accepted for publication 27 September 2017
Published 1 November 2017 Volume 2017:12 Pages 8085—8099
DOI https://doi.org/10.2147/IJN.S149070
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Abstract: Due to the widespread applications of zinc oxide nanoparticles (ZnO
NPs), the potential exposure of workers, consumers, and scientists to these
particles has increased. This potential for exposure has attracted extensive
attention in the science community. Many studies have examined the
toxicological profile of ZnO NPs in the immune system, digestive system,
however, information regarding the toxicity of ZnO NPs in the nervous system is
scarce. In this study, we detected the cytotoxicity of two types of ZnO NPs of
various sizes – ZnOa NPs and ZnOb NPs – and we characterized the shedding
ability of zinc ions within culture medium and the cytoplasm. We found that reactive oxygen species played a crucial role in ZnO
NP-induced cytotoxicity, likely because zinc ions were leached from ZnO NPs.
Apoptosis and cytoskeleton changes were also toxic responses induced by the ZnO
NPs, and ZnOb NPs induced more significant toxic responses
than ZnOa NPs in SHSY5Y cells. In conclusion, ZnO NPs
induced toxic responses in SHSY5Y cells in a size-dependent manner, which can
probably be attributed to their ion-shedding ability.
Keywords: zinc
oxide, nanoparticles, SHSY5Y cells, reactive oxygen species, apoptosis, cell
cytoskeleton