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已发表论文
MicroRNAs 作为诊断骨肉瘤的新型诊断性生物标记物：一项综合分析
Authors Liu H, Li P, Chen L, Jian C, Li ZH, Yu AX
Received 14 June 2017
Accepted for publication 17 August 2017
Published 1 November 2017 Volume 2017:10 Pages 5229—5236
DOI https://doi.org/10.2147/OTT.S143974
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Dr Jianmin Xu
Abstract: MicroRNAs
(miRNAs) have been considered as promising diagnostic biomarkers for many
diseases, especially for cancers. Numerous studies have reported the value of
miRNAs in the diagnosis of osteosarcoma (OS), but the results vary greatly
across different studies. Therefore, we conducted this meta-analysis to assess
the prospective diagnostic value of miRNAs in diagnosing OS. All relevant
articles from prior to July 28, 2017 were selected from PubMed, EMBASE, Web of
Science, Cochrane Library, Chinese National Knowledge Infrastructure, and
Wan-fang databases. The Quality Assessment of Diagnostic Accuracy Studies-2
(QUADAS-2) was performed to assess the quality of each article. A
random-effects model was used to pool the sensitivity and specificity of the
positive likelihood ratio (PLR), negative likelihood ratio (NLR) and,
diagnostic odds ratio (DOR) together with the area under the curve (AUC) to
evaluate diagnostic values. Seventeen studies
comprising 2,214 OS patients and 1,534 healthy humans were included in our
meta-analysis. The pooled estimations indicated that the miRNAs had a high
accuracy for diagnosing OS, with a sensitivity of 0.82, specificity of 0.88,
PLR of 10.96, NLR of 0.20, DOR of 54.55, and AUC of 0.93. Twenty-five miRNAs
were differentially expressed in OS, including 17 upregulated and 8
downregulated. These miRNAs were correlated with survival time, tumor size,
cell differentiation, tumor node metastasis staging, metastasis, tumor/cell
invasion, pathological type, and response to radiotherapy and chemotherapy.
Several different miRNAs are expressed in OS, and some of them might be
potential biomarkers for the early diagnosis of OS.
Keywords: osteosarcoma, miRNAs, diagnosis, biomarker, meta-analysis
Keywords: osteosarcoma, miRNAs, diagnosis, biomarker, meta-analysis
