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已发表论文
多孔 Se@SiO2 纳米球通过抗氧化应激治疗百草枯 (paraquat) 诱导的急性肺损伤
Authors Zhu Y, Deng G, Ji A, Yao J, Meng X, Wang J, Wang Q, Wang Q, Wang R
Received 4 June 2017
Accepted for publication 23 August 2017
Published 27 September 2017 Volume 2017:12 Pages 7143—7152
DOI https://doi.org/10.2147/IJN.S143192
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Farooq Shiekh
Peer reviewer comments 3
Editor who approved publication: Professor Dongwoo Khang
Abstract: Acute paraquat (PQ)
poisoning is one of the most common forms of pesticide poisoning. Oxidative
stress and inflammation are thought to be important mechanisms in PQ-induced
acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals
directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative stress
and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells
were used in this study. Rats were categorized into 3 groups: control (n=6), PQ
(n=18), and PQ + Se@SiO2 (n=18). The
PQ and PQ + Se@SiO2 groups were randomly and
evenly divided into 3 sub-groups according to different time points (24, 48 and
72 h) after PQ treatment. Porous Se@SiO2 nanospheres
1 mg/kg (in the PQ + Se@SiO2 group) were
administered via intraperitoneal injection every 24 h. Expression levels of
reduced glutathione, malondialdehyde, superoxide dismutase, reactive oxygen
species (ROS), nuclear factor-κB (NF-κB), phosphorylated NF-κB (p-NF-κB), tumor
necrosis factor-α and interleukin-1β were detected, and a histological analysis
of rat lung tissues was performed. The results showed that the levels of ROS,
malondialdehyde, NF-κB, p-NF-κB, tumor necrosis factor-α and interleukin-1β
were markedly increased after PQ treatment. Glutathione and superoxide
dismutase levels were reduced. However, treatment with porous Se@SiO2 nanospheres markedly alleviated PQ-induced
oxidative stress and inflammation. Additionally, the results from histological
examinations and wet-to-dry weight ratios of rat lung tissues showed that lung
damage was reduced after porous Se@SiO2 nanosphere treatment. These data
indicate that porous Se@SiO2 nanospheres
may reduce NF-κB, p-NF-κB and inflammatory cytokine levels by inhibiting ROS in
PQ-induced ALI. This study demonstrates that porous Se@SiO2 nanospheres may be a therapeutic method for
use in the future for PQ poisoning.
Keywords: porous Se@SiO2 nanospheres, acute lung injury, paraquat poisoning, oxidative stress, inflammatory cytokines, ROS, NF-kappa
Keywords: porous Se@SiO2 nanospheres, acute lung injury, paraquat poisoning, oxidative stress, inflammatory cytokines, ROS, NF-kappa
