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已发表论文
冬虫夏草及其生物活性成分的抗炎机制和转化意义
Authors Xie J, Xu J , Fan Q , Chen Y
Received 20 November 2025
Accepted for publication 14 February 2026
Published 21 February 2026 Volume 2026:19 582921
DOI https://doi.org/10.2147/JIR.S582921
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Shouya Feng
Jiahao Xie,* Jingwen Xu,* Qi Fan, Yuchi Chen
School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuchi Chen, School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China, Email btcyc@sina.com
Abstract: Cordyceps sinensis, an important medicinal fungus in traditional Chinese medicine, has gained increasing attention for its diverse pharmacological activities, particularly its anti-inflammatory properties. Its principal bioactive components, including cordycepin, cordycepic acid, polysaccharides, and sterols, exert significant protective effects in a wide range of inflammation-related diseases, primarily covering respiratory diseases, autoimmune disorders, neuroinflammatory conditions, and metabolic and gastrointestinal syndromes. These compounds act mainly by modulating key signaling pathways, including NF-κB, MAPK, TLR4/MyD88, PI3K/Akt, JAK/STAT, and Nrf2/HO-1. This review summarizes recent progress in the identification of anti-inflammatory components of Cordyceps sinensis and their mechanisms of action, highlights current challenges in clinical translation, and outlines future research directions. Collectively, these findings emphasize the broad potential of Cordyceps sinensis as a multi-target natural product–based anti-inflammatory therapy.
Keywords: Cordyceps sinensis, bioactive components, anti-inflammatory mechanisms, inflammation-related diseases
School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuchi Chen, School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China, Email btcyc@sina.com
Abstract: Cordyceps sinensis, an important medicinal fungus in traditional Chinese medicine, has gained increasing attention for its diverse pharmacological activities, particularly its anti-inflammatory properties. Its principal bioactive components, including cordycepin, cordycepic acid, polysaccharides, and sterols, exert significant protective effects in a wide range of inflammation-related diseases, primarily covering respiratory diseases, autoimmune disorders, neuroinflammatory conditions, and metabolic and gastrointestinal syndromes. These compounds act mainly by modulating key signaling pathways, including NF-κB, MAPK, TLR4/MyD88, PI3K/Akt, JAK/STAT, and Nrf2/HO-1. This review summarizes recent progress in the identification of anti-inflammatory components of Cordyceps sinensis and their mechanisms of action, highlights current challenges in clinical translation, and outlines future research directions. Collectively, these findings emphasize the broad potential of Cordyceps sinensis as a multi-target natural product–based anti-inflammatory therapy.
Keywords: Cordyceps sinensis, bioactive components, anti-inflammatory mechanisms, inflammation-related diseases