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已发表论文
苦参碱在肝脏疾病中的作用：机制见解和治疗潜力
Authors Wen W, Xia J, Liu G, Wang C
Received 28 October 2025
Accepted for publication 2 February 2026
Published 7 February 2026 Volume 2026:20 577265
DOI https://doi.org/10.2147/DDDT.S577265
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Georgios Panos
Wen Wen,1,2,* Jiayan Xia,1,3,* Gang Liu,1,2 Cheng Wang1,2
1School of Clinical Medical, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 3Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Gang Liu, School of Clinical Medical, Chengdu Medical College, Chengdu, 610500, People’s Republic of China, Email cyfygcp@163.com Cheng Wang, School of Clinical Medical, Chengdu Medical College, Chengdu, 610500, People’s Republic of China, Email chengwang@cmc.edu.cn
Abstract: Matrine (C15H24N2O), a quinolizidine alkaloid abundant in Sophora flavescens and other legumes, has attracted considerable attention in recent years due to its remarkable pharmacological effects against a range of liver diseases. Extensive research has demonstrated that matrine exhibits significant therapeutic potential in the prevention and treatment of various liver disorders, including liver injury of diverse etiologies, metabolic-associated fatty liver disease, liver fibrosis and hepatocellular carcinoma. This review integrates recent literature from CNKI, Web of Science, ScienceDirect and PubMed to summarize advances in the application of matrine for liver disease therapy. According to current data, the hepatoprotective effects of matrine involve multiple molecular mechanisms, such as inhibition of inflammatory responses, reduction of oxidative stress, alleviation of endoplasmic reticulum stress, improvement of insulin resistance, mitigation of lipid peroxidation, as well as suppression of hepatocellular carcinoma cell proliferation, invasion, and migration through induction of autophagy and apoptosis. Notably, several signaling pathways, including NF-κB, Nrf2, HSF1/PGC-1α, PI3K/AKT/mTOR, JAK2/STAT3, RhoA/ROCK and Mst1-JNK, have been identified as critical mediators of its hepatoprotective actions. Toxicological data indicate that excessive doses or prolonged exposure to matrine may induce multisystem toxicity, affecting the liver, kidneys, nervous system and gastrointestinal tract. Pharmacokinetic studies reveal that matrine undergoes rapid absorption, exhibits moderate oral bioavailability and is subject to relatively rapid metabolic clearance. Additionally, this review outlines the natural sources, physicochemical properties and current research challenges associated with matrine, aiming to provide a solid theoretical foundation and clinical translation in the treatment of liver diseases.
Keywords: liver diseases, matrine, hepatoprotection, mechanisms, toxicity, pharmacokinetics
1School of Clinical Medical, Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, People’s Republic of China; 3Department of Pediatrics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Gang Liu, School of Clinical Medical, Chengdu Medical College, Chengdu, 610500, People’s Republic of China, Email cyfygcp@163.com Cheng Wang, School of Clinical Medical, Chengdu Medical College, Chengdu, 610500, People’s Republic of China, Email chengwang@cmc.edu.cn
Abstract: Matrine (C15H24N2O), a quinolizidine alkaloid abundant in Sophora flavescens and other legumes, has attracted considerable attention in recent years due to its remarkable pharmacological effects against a range of liver diseases. Extensive research has demonstrated that matrine exhibits significant therapeutic potential in the prevention and treatment of various liver disorders, including liver injury of diverse etiologies, metabolic-associated fatty liver disease, liver fibrosis and hepatocellular carcinoma. This review integrates recent literature from CNKI, Web of Science, ScienceDirect and PubMed to summarize advances in the application of matrine for liver disease therapy. According to current data, the hepatoprotective effects of matrine involve multiple molecular mechanisms, such as inhibition of inflammatory responses, reduction of oxidative stress, alleviation of endoplasmic reticulum stress, improvement of insulin resistance, mitigation of lipid peroxidation, as well as suppression of hepatocellular carcinoma cell proliferation, invasion, and migration through induction of autophagy and apoptosis. Notably, several signaling pathways, including NF-κB, Nrf2, HSF1/PGC-1α, PI3K/AKT/mTOR, JAK2/STAT3, RhoA/ROCK and Mst1-JNK, have been identified as critical mediators of its hepatoprotective actions. Toxicological data indicate that excessive doses or prolonged exposure to matrine may induce multisystem toxicity, affecting the liver, kidneys, nervous system and gastrointestinal tract. Pharmacokinetic studies reveal that matrine undergoes rapid absorption, exhibits moderate oral bioavailability and is subject to relatively rapid metabolic clearance. Additionally, this review outlines the natural sources, physicochemical properties and current research challenges associated with matrine, aiming to provide a solid theoretical foundation and clinical translation in the treatment of liver diseases.
Keywords: liver diseases, matrine, hepatoprotection, mechanisms, toxicity, pharmacokinetics