120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
肥胖相关心脏纤维化：机制和新兴治疗靶点
Authors Zhou D, Tan Y, Zhao J, Wang S, Wang Z , Bai M, Niu X, Zhang Z
Received 14 September 2025
Accepted for publication 22 January 2026
Published 7 February 2026 Volume 2026:22 567568
DOI https://doi.org/10.2147/VHRM.S567568
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Roland Asmar
Dan Zhou,1– 4,* Yingxin Tan,5,* Jing Zhao,2– 4 Shuping Wang,1– 4 Zheng Wang,6 Ming Bai,2– 4 Xiaowei Niu,2– 4 Zheng Zhang2– 4
1The First Clinical Medical School, Lanzhou University, Lanzhou, People’s Republic of China; 2Heart Center, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 3Gansu Provincial Clinical Research Center for Cardiovascular Diseases, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 4Gansu Key Laboratory of Cardiovascular Diseases, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 5Department of Vascular Surgery, General Surgery, the First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 6Gansu University of Chinese Medicine, Lanzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaowei Niu, Email niuxwccu@126.com Zheng Zhang, Email zhangzhengccu24@126.com
Abstract: Obesity and cardiovascular disease are major, globally prevalent, and closely interrelated health challenges. Cardiac fibrosis represents the common pathological endpoint of multiple cardiac diseases. This review systematically synthesizes the mechanisms underlying obesity related cardiac fibrosis. It elaborates on how inflammatory factors, cytokines, and miRNAs, acting on adipose tissue and cardiac cells, drive a series of biological processes—including oxidative stress, activation of the renin angiotensin aldosterone system, autophagy dysregulation, and metabolic dysfunction—ultimately leading to obesity associated cardiomyopathy characterized by ventricular remodeling, heart failure, and atrial fibrillation. Potential therapeutic targets for this condition are also examined. Furthermore, this review discusses potential therapeutic targets for this condition, which will provide a critical theoretical foundation for the development of novel strategies aimed at preventing or even reversing obesity related fibrotic heart disease.
Keywords: obesity, cardiac fibrosis, cardiac dysfunction, inflammation, cytokine, RAAS, autophagy
1The First Clinical Medical School, Lanzhou University, Lanzhou, People’s Republic of China; 2Heart Center, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 3Gansu Provincial Clinical Research Center for Cardiovascular Diseases, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 4Gansu Key Laboratory of Cardiovascular Diseases, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 5Department of Vascular Surgery, General Surgery, the First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 6Gansu University of Chinese Medicine, Lanzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaowei Niu, Email niuxwccu@126.com Zheng Zhang, Email zhangzhengccu24@126.com
Abstract: Obesity and cardiovascular disease are major, globally prevalent, and closely interrelated health challenges. Cardiac fibrosis represents the common pathological endpoint of multiple cardiac diseases. This review systematically synthesizes the mechanisms underlying obesity related cardiac fibrosis. It elaborates on how inflammatory factors, cytokines, and miRNAs, acting on adipose tissue and cardiac cells, drive a series of biological processes—including oxidative stress, activation of the renin angiotensin aldosterone system, autophagy dysregulation, and metabolic dysfunction—ultimately leading to obesity associated cardiomyopathy characterized by ventricular remodeling, heart failure, and atrial fibrillation. Potential therapeutic targets for this condition are also examined. Furthermore, this review discusses potential therapeutic targets for this condition, which will provide a critical theoretical foundation for the development of novel strategies aimed at preventing or even reversing obesity related fibrotic heart disease.
Keywords: obesity, cardiac fibrosis, cardiac dysfunction, inflammation, cytokine, RAAS, autophagy