120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
癌症合并心血管疾病相关靶点和机制研究进展
Received 15 November 2025
Accepted for publication 27 January 2026
Published 7 February 2026 Volume 2026:19 581768
DOI https://doi.org/10.2147/OTT.S581768
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Sanjay Singh
Jianing Li,1 Peili Wang2
1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China
Correspondence: Peili Wang, Email 191593690@qq.com
Purpose: Cancers complicated by cardiovascular diseases (CVDs) are increasingly becoming major limiting factors affecting patients’ long-term quality of life and clinical outcomes. Systematic identification of therapeutic targets and their clinical development status is crucial for optimizing treatment strategies. Therefore, this study aimed to establish a target-based analytical framework to systematically map the distribution, developmental stage, maturity, and mechanistic characteristics of clinical trials investigating tumors co-occurring with CVD, thereby identifying potential therapeutic targets.
Patients and Methods: We analyzed clinical trial data on treatments for cancers complicated by CVDs. A total of 58 clinical trials were included and examined across multiple dimensions, including target distribution, development stage, and disease relevance.
Results: Forty-five therapeutic targets were identified, with coagulation Factor X, thrombin, and serpin family C member 1 (SERPINC1) emerging as high-frequency core targets. Most studies focused on coagulation, inflammation, and endothelial pathways. Significant variations were observed in completion status and research phase across different targets, with some demonstrating dual therapeutic and cardiovascular regulatory potentials.
Conclusion: Coagulation and endothelium-related targets emerged as key links between cancer progression and cardiovascular complications. SERPINC1 and 3-hydroxy-3-methylglutaryl-CoA reductase showed potential for synergistic therapy. This study provides a comprehensive overview of targeted therapies for tumors with concomitant CVD, revealing key pathways and under-explored mechanisms. It offers data-driven insights and directional guidance for precision treatment design.
Keywords: cardiovascular disease, therapeutic target, cancer, clinical trial, cardiovascular complication
1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China
Correspondence: Peili Wang, Email 191593690@qq.com
Purpose: Cancers complicated by cardiovascular diseases (CVDs) are increasingly becoming major limiting factors affecting patients’ long-term quality of life and clinical outcomes. Systematic identification of therapeutic targets and their clinical development status is crucial for optimizing treatment strategies. Therefore, this study aimed to establish a target-based analytical framework to systematically map the distribution, developmental stage, maturity, and mechanistic characteristics of clinical trials investigating tumors co-occurring with CVD, thereby identifying potential therapeutic targets.
Patients and Methods: We analyzed clinical trial data on treatments for cancers complicated by CVDs. A total of 58 clinical trials were included and examined across multiple dimensions, including target distribution, development stage, and disease relevance.
Results: Forty-five therapeutic targets were identified, with coagulation Factor X, thrombin, and serpin family C member 1 (SERPINC1) emerging as high-frequency core targets. Most studies focused on coagulation, inflammation, and endothelial pathways. Significant variations were observed in completion status and research phase across different targets, with some demonstrating dual therapeutic and cardiovascular regulatory potentials.
Conclusion: Coagulation and endothelium-related targets emerged as key links between cancer progression and cardiovascular complications. SERPINC1 and 3-hydroxy-3-methylglutaryl-CoA reductase showed potential for synergistic therapy. This study provides a comprehensive overview of targeted therapies for tumors with concomitant CVD, revealing key pathways and under-explored mechanisms. It offers data-driven insights and directional guidance for precision treatment design.
Keywords: cardiovascular disease, therapeutic target, cancer, clinical trial, cardiovascular complication