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已发表论文
早期诊断的潜在生物标志物：糖尿病周围神经病变发病机制认识进展
Authors Lyu Q, Tan Y, Zeng X , Peng S, Lee M
Received 10 October 2025
Accepted for publication 27 January 2026
Published 10 February 2026 Volume 2026:19 568751
DOI https://doi.org/10.2147/DMSO.S568751
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Qingqin Lyu,1,* Yanyan Tan,2,3,* Xianqi Zeng,2,3,* Siping Peng,2,3 Maosheng Lee2,3
1National Health Data Institute, Shenzhen, 518033, People’s Republic of China; 2The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518033, People’s Republic of China; 3Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Siping Peng, Email spring201220@163.com Maosheng Lee, Email realsmile365@163.com
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus. The most common type is distal symmetric polyneuropathy, and lesions frequently lead to disabling neuropathic pain and even amputation, increasing the risk of death. At present, the pathogenesis of DPN has not been clarified, and its insidious onset and lack of obvious symptoms in most patients in the early stages often lead to delayed diagnosis, which is unfavourable for prevention and treatment. This article provides an overview of the existing research progress on early diagnostic markers of DPN, especially oxidative stress-related markers, neural tissue damage markers, inflammation-related markers, neurovascular damage markers, and gene-related markers, in the hope that it can provide a reference for early diagnosis and treatment of DPN, and slow down the occurrence and development of DPN.
Keywords: diabetic peripheral neuropathy, diagnostic markers, pathogenesis, diabetes mellitus
1National Health Data Institute, Shenzhen, 518033, People’s Republic of China; 2The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518033, People’s Republic of China; 3Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Siping Peng, Email spring201220@163.com Maosheng Lee, Email realsmile365@163.com
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus. The most common type is distal symmetric polyneuropathy, and lesions frequently lead to disabling neuropathic pain and even amputation, increasing the risk of death. At present, the pathogenesis of DPN has not been clarified, and its insidious onset and lack of obvious symptoms in most patients in the early stages often lead to delayed diagnosis, which is unfavourable for prevention and treatment. This article provides an overview of the existing research progress on early diagnostic markers of DPN, especially oxidative stress-related markers, neural tissue damage markers, inflammation-related markers, neurovascular damage markers, and gene-related markers, in the hope that it can provide a reference for early diagnosis and treatment of DPN, and slow down the occurrence and development of DPN.
Keywords: diabetic peripheral neuropathy, diagnostic markers, pathogenesis, diabetes mellitus