120017
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.6 Breast Cancer (Dove Med Press)
- 4.3 Clin Epidemiol
- 2.6 Cancer Manag Res
- 3.2 Infect Drug Resist
- 4.1 Clin Interv Aging
- 6.1 Drug Des Dev Ther
- 4.1 Int J Chronic Obstr
- 8.7 Int J Nanomed
- 2.5 Int J Women's Health
- 3.2 Neuropsych Dis Treat
- 2.4 OncoTargets Ther
- 2.6 Patient Prefer Adher
- 2.6 Ther Clin Risk Manag
- 3.1 J Pain Res
- 3.5 Diabet Metab Synd Ob
- 4.5 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 2.4 Pharmgenomics Pers Med
- 2.6 Risk Manag Healthc Policy
- 4.6 J Inflamm Res
- 2.3 Int J Gen Med
- 3.9 J Hepatocell Carcinoma
- 3.3 J Asthma Allergy
- 2.5 Clin Cosmet Investig Dermatol
- 3.0 J Multidiscip Healthc
已发表论文
高输出造口液体和电解质管理策略：一项系统综述和证据总结
Authors Wen A , Jiao Y, Wang N, Xu J, Xu X, Du L, Lv L
Received 3 September 2025
Accepted for publication 24 January 2026
Published 10 February 2026 Volume 2026:19 564953
DOI https://doi.org/10.2147/JMDH.S564953
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr David C. Mohr
Anna Wen,1,* Yanxia Jiao,2,* Ning Wang,2 Jie Xu,1 Xinyue Xu,1 Li Du,1 Lin Lv3
1Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Wound and Ostomy Care Center, Outpatient Department, Gansu Provincial Hospital, Lanzhou, Gansu, People’s Republic of China; 3Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Wound and Ostomy Care Center, Outpatient Department, Gansu Provincial Hospital, NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Lanzhou, Gansu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lin Lv, Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Wound and Ostomy Care Center, Outpatient Department, Gansu Provincial Hospital, NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, #28 Yanxi Road, Chenguan District, Lanzhou, Gansu, People’s Republic of China, Email lzu_lvl@lzu.edu.cn
Purpose: This study aimed to explore intervention strategies for fluid and electrolyte regulation in patients with high-output stomas, to optimize their clinical outcomes and quality of life.
Results: Fifteen experimental and semi-experimental studies were systematically reviewed. Interventions were categorized into five types by therapeutic purpose and route: gastrointestinal motility/anti-secretory agents, Glucagon-like Peptide-1/2 (GLP-1/2) analogs, rehydration/electrolyte supplements, micronutrient supplements, and dietary restriction. Key HOS complications included hyponatremia, hypomagnesemia, metabolic acidosis, hypokalemia, hypocalcemia, and kidney injury.
Conclusion: Hydro-electrolyte management in patients with HOS requires a multidisciplinary approach that integrates fluid management, pharmacotherapy, nutritional support, and surgical intervention. This framework may reduce dehydration-related readmission and improve outcomes. Future large-scale prospective studies are warranted to verify the efficacy, safety, and novel therapies, explore new therapeutic targets/drugs, and develop standardized guidelines, with an emphasis on individualized management for complex cases and prioritizing patient quality of life.
Keywords: dehydration prevention, hyponatremia, hypomagnesemia, pharmacotherapy, multidisciplinary team
1Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China; 2Wound and Ostomy Care Center, Outpatient Department, Gansu Provincial Hospital, Lanzhou, Gansu, People’s Republic of China; 3Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Wound and Ostomy Care Center, Outpatient Department, Gansu Provincial Hospital, NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Lanzhou, Gansu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lin Lv, Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Wound and Ostomy Care Center, Outpatient Department, Gansu Provincial Hospital, NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, #28 Yanxi Road, Chenguan District, Lanzhou, Gansu, People’s Republic of China, Email lzu_lvl@lzu.edu.cn
Purpose: This study aimed to explore intervention strategies for fluid and electrolyte regulation in patients with high-output stomas, to optimize their clinical outcomes and quality of life.
Results: Fifteen experimental and semi-experimental studies were systematically reviewed. Interventions were categorized into five types by therapeutic purpose and route: gastrointestinal motility/anti-secretory agents, Glucagon-like Peptide-1/2 (GLP-1/2) analogs, rehydration/electrolyte supplements, micronutrient supplements, and dietary restriction. Key HOS complications included hyponatremia, hypomagnesemia, metabolic acidosis, hypokalemia, hypocalcemia, and kidney injury.
Conclusion: Hydro-electrolyte management in patients with HOS requires a multidisciplinary approach that integrates fluid management, pharmacotherapy, nutritional support, and surgical intervention. This framework may reduce dehydration-related readmission and improve outcomes. Future large-scale prospective studies are warranted to verify the efficacy, safety, and novel therapies, explore new therapeutic targets/drugs, and develop standardized guidelines, with an emphasis on individualized management for complex cases and prioritizing patient quality of life.
Keywords: dehydration prevention, hyponatremia, hypomagnesemia, pharmacotherapy, multidisciplinary team