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已发表论文
中心性肥胖和糖尿病与甲状腺结节的关联：中国成人 3.2 年前瞻性研究
Authors Liu R, Zhuang H, Wang R, Peng N , Hu Y, Zhang Q, Zheng J, Li D, He J, Shi L, Zhang M
Received 7 November 2024
Accepted for publication 29 May 2025
Published 10 February 2026 Volume 2026:19 498295
DOI https://doi.org/10.2147/DMSO.S498295
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Liang Wang
Ruoyi Liu,1,* Huijun Zhuang,1,* Rui Wang,1 Nianchun Peng,1 Ying Hu,1 Qiao Zhang,2 Jing Zheng,1 Dan Li,1 Juan He,1 Lixin Shi,2 Miao Zhang1
1Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2Department of Endocrinology and Metabolism, GuiQian International General Hospital, Guiyang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Miao Zhang, Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, People’s Republic of China, Tel +86-085186774238, Email 20057544@qq.com Ruoyi Liu, Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, People’s Republic of China, Tel +86-085186774238, Email liuruoyi731@126.com
Purpose: We investigated the association of central obesity and glucose metabolism with thyroid nodule (TN) risk and explored whether diabetes/central obesity altered TN risk.
Methods: Data were collected in the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study, which involved cross-sectional (May–August 2011) and longitudinal cohorts (July–October 2014; 3.2-year follow-up). In all, 8995 subjects were enrolled in the baseline survey; the 5655 subjects evaluated during the 3.2-year follow-up were included in this study. All subjects underwent body measurements, laboratory tests, and thyroid ultrasonography.
Results: Among 5655 participants, 420 had TNs. Participants with central obesity or abnormal glucose metabolism had significantly higher TN risk than participants without central obesity (OR: 1.233; 95% CI: 1.009– 1.507) or abnormal glucose metabolism (OR: 1.257; 95% CI: 1.025– 1.541). After adjustments for age and sex, this significance was retained for central obesity. Among participants with central obesity, prediabetes (OR: 1.483, 95% CI: 1.016– 2.163) and diabetes (OR: 1.622, 95% CI: 1.078– 2.407) were associated with TNs, when compared to the euglycemic subgroup (P trend = 0.040). No similar result was observed among participants without central obesity. During follow-up, the incidence rate ratio (IRR) for TNs was 1.026 (95% CI: 1.006– 1.050) among those with new-onset central obesity and 1.025 (95% CI: 1.006– 1.049) among those with chronic central obesity, as compared with those without central obesity. No significant associations were found among groups based on dynamic changes in glucose metabolism. Only in the chronic central obesity subgroup, new-onset prediabetes (IRR: 1.092, 95% CI: 1.020– 1.169) and diabetes (IRR: 1.103, 95% CI: 1.031– 1.189) significantly increased TN risk, as compared with euglycemia.
Conclusion: TNs are associated with central obesity and abnormal glucose metabolism. Chronic/new-onset central obesity increased TN risk. New-onset prediabetes/diabetes amplified TN risk among people with chronic central obesity.
Keywords: diabetes, glucose metabolism, obesity, thyroid nodule
1Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2Department of Endocrinology and Metabolism, GuiQian International General Hospital, Guiyang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Miao Zhang, Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, People’s Republic of China, Tel +86-085186774238, Email 20057544@qq.com Ruoyi Liu, Department of Endocrinology and Metabolism, Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Road, Yunyan District, Guiyang, People’s Republic of China, Tel +86-085186774238, Email liuruoyi731@126.com
Purpose: We investigated the association of central obesity and glucose metabolism with thyroid nodule (TN) risk and explored whether diabetes/central obesity altered TN risk.
Methods: Data were collected in the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study, which involved cross-sectional (May–August 2011) and longitudinal cohorts (July–October 2014; 3.2-year follow-up). In all, 8995 subjects were enrolled in the baseline survey; the 5655 subjects evaluated during the 3.2-year follow-up were included in this study. All subjects underwent body measurements, laboratory tests, and thyroid ultrasonography.
Results: Among 5655 participants, 420 had TNs. Participants with central obesity or abnormal glucose metabolism had significantly higher TN risk than participants without central obesity (OR: 1.233; 95% CI: 1.009– 1.507) or abnormal glucose metabolism (OR: 1.257; 95% CI: 1.025– 1.541). After adjustments for age and sex, this significance was retained for central obesity. Among participants with central obesity, prediabetes (OR: 1.483, 95% CI: 1.016– 2.163) and diabetes (OR: 1.622, 95% CI: 1.078– 2.407) were associated with TNs, when compared to the euglycemic subgroup (P trend = 0.040). No similar result was observed among participants without central obesity. During follow-up, the incidence rate ratio (IRR) for TNs was 1.026 (95% CI: 1.006– 1.050) among those with new-onset central obesity and 1.025 (95% CI: 1.006– 1.049) among those with chronic central obesity, as compared with those without central obesity. No significant associations were found among groups based on dynamic changes in glucose metabolism. Only in the chronic central obesity subgroup, new-onset prediabetes (IRR: 1.092, 95% CI: 1.020– 1.169) and diabetes (IRR: 1.103, 95% CI: 1.031– 1.189) significantly increased TN risk, as compared with euglycemia.
Conclusion: TNs are associated with central obesity and abnormal glucose metabolism. Chronic/new-onset central obesity increased TN risk. New-onset prediabetes/diabetes amplified TN risk among people with chronic central obesity.
Keywords: diabetes, glucose metabolism, obesity, thyroid nodule