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已发表论文
脓毒症中脑区介导的神经免疫调节：研究进展和治疗前景
Authors Zhou X , Tang Y, Chen H, Huang W, Qiu H
Received 9 October 2025
Accepted for publication 24 January 2026
Published 10 February 2026 Volume 2026:19 570541
DOI https://doi.org/10.2147/JIR.S570541
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Anh Ngo
Xuechun Zhou, Ying Tang, Hui Chen, Wei Huang, Haibo Qiu
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China
Correspondence: Wei Huang, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China, Email whuang@seu.edu.cn Haibo Qiu, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China, Email haiboq2000@163.com
Abstract: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, lacks effective treatments targeting its pervasive immune dysregulation. Despite growing interest in neuroimmune interactions, there remains a fragmented understanding of how distinct brain regions integrate peripheral immune signals and orchestrate systemic immune responses in sepsis. Emerging evidence highlights the brain as a master regulator of systemic immunity in sepsis through the neuro-immune-endocrine network. This review summarizes recent advances in understanding how distinct brain regions, including the hypothalamus, brainstem, cortex and cerebellum, sense peripheral inflammation and feedback-regulate systemic immune responses via dedicated neural circuits, neurotransmitters, and autonomic outputs. We also highlight the therapeutic potential of neuromodulation techniques designed to target these central circuits and discuss their implications for developing future precision medicine strategies in sepsis management.
Keywords: sepsis, neuroimmunity, brain regions, central nervous system
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China
Correspondence: Wei Huang, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China, Email whuang@seu.edu.cn Haibo Qiu, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People’s Republic of China, Email haiboq2000@163.com
Abstract: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, lacks effective treatments targeting its pervasive immune dysregulation. Despite growing interest in neuroimmune interactions, there remains a fragmented understanding of how distinct brain regions integrate peripheral immune signals and orchestrate systemic immune responses in sepsis. Emerging evidence highlights the brain as a master regulator of systemic immunity in sepsis through the neuro-immune-endocrine network. This review summarizes recent advances in understanding how distinct brain regions, including the hypothalamus, brainstem, cortex and cerebellum, sense peripheral inflammation and feedback-regulate systemic immune responses via dedicated neural circuits, neurotransmitters, and autonomic outputs. We also highlight the therapeutic potential of neuromodulation techniques designed to target these central circuits and discuss their implications for developing future precision medicine strategies in sepsis management.
Keywords: sepsis, neuroimmunity, brain regions, central nervous system